The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin
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Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.Cholesterol Modifies Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes.Free-Energy Landscape of the Amino-Terminal Fragment of Huntingtin in Aqueous SolutionFibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine coreMonomeric, oligomeric and polymeric proteins in huntington disease and other diseases of polyglutamine expansionPolyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state nuclear magnetic resonance.Probing the Huntingtin 1-17 membrane anchor on a phospholipid bilayer by using all-atom simulationsThe emerging role of the first 17 amino acids of huntingtin in Huntington's diseaseHuntingtin N-Terminal Monomeric and Multimeric Structures Destabilized by Covalent Modification of Heteroatomic Residues.Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophyα-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane.Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding.A flexible polyglutamine hinge opens new doors for understanding huntingtin functionPolyglutamine aggregates impair lipid membrane integrity and enhance lipid membrane rigidity.Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.Aggregation behavior of chemically synthesized, full-length huntingtin exon1.Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.Investigation of temperature induced mechanical changes in supported bilayers by variants of tapping mode atomic force microscopy.Lysine residues in the N-terminal huntingtin amphipathic α-helix play a key role in peptide aggregation.The Functional Amyloid Orb2A Binds to Lipid Membranes.Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes.Assembly of Huntingtin headpiece into α-helical bundles.Selection pressure on human STR loci and its relevance in repeat expansion disease.
P2860
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P2860
The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin
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2013 nî lūn-bûn
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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name
The interaction of polyglutami ...... ces associated with huntingtin
@en
type
label
The interaction of polyglutami ...... ces associated with huntingtin
@en
prefLabel
The interaction of polyglutami ...... ces associated with huntingtin
@en
P2093
P2860
P356
P1476
The interaction of polyglutami ...... ces associated with huntingtin
@en
P2093
C Samuel Umbaugh
Justin Legleiter
Karlina J Kauffman
Kathleen A Burke
Shelli L Frey
P2860
P304
14993-15005
P356
10.1074/JBC.M112.446237
P407
P577
2013-04-09T00:00:00Z