about
What can we learn about autism from studying fragile X syndrome?FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autismmTOR signaling: at the crossroads of plasticity, memory and diseaseThe PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia.Single-Nucleotide Mutations in FMR1 Reveal Novel Functions and Regulatory Mechanisms of the Fragile X Syndrome Protein FMRPAdvances in the Understanding of the Gabaergic Neurobiology of FMR1 Expanded Alleles Leading to Targeted Treatments for Fragile X Spectrum DisorderCharacterizing autism spectrum disorders by key biochemical pathways.Dysregulation and restoration of translational homeostasis in fragile X syndromeDysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of AutismThe neurology of mTORNetworking in autism: leveraging genetic, biomarker and model system findings in the search for new treatmentsChannelopathy pathogenesis in autism spectrum disordersFragile X syndrome and targeted treatment trials.Unstable mutations in the FMR1 gene and the phenotypesThe pathophysiology of fragile X (and what it teaches us about synapses)From Learning to Memory: What Flies Can Tell Us about Intellectual Disability TreatmentTargeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromesConsolidation and translation regulationElevated levels of the vesicular monoamine transporter and a novel repetitive behavior in the Drosophila model of fragile X syndromeIncreased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and BackmTOR and MAPK: from localized translation control to epilepsyCommon mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disordersFMRP targets distinct mRNA sequence elements to regulate protein expressionRoles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalizationDegradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in ZebrafishPositive feedback regulation of Akt-FMRP pathway protects neurons from cell deathIdentification and characterisation of Simiate, a novel protein linked to the fragile X syndromeModeling autistic features in animalsTranslational regulation of NeuroD1 expression by FMRP: involvement in glutamatergic neuronal differentiation of cultured rat primary neural progenitor cellsPhosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model.Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background.In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndromeFrom FMRP function to potential therapies for fragile X syndrome.Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model.Modeling fragile X syndrome in the Fmr1 knockout mouseMetabotropic glutamate receptors: from the workbench to the bedside.
P2860
Q24613049-16BFF2EC-75C4-4385-BFCC-0BD6E4ACF6FBQ24631425-546D9477-5872-458B-89AC-B07AA956A762Q24647655-E1938BB8-CDF3-4B51-AD7B-39968465E74CQ26766054-877851A1-9EDD-4ECB-BAF0-CBB376D7E07DQ26773167-B3C547BE-953C-4446-A8B9-D25674F407B3Q26781265-A56BDDD5-02AA-46D3-B7D3-96704DB37C16Q26781645-DFAD05AF-72D1-413D-BB88-A2E0060D301EQ26782616-2C1F67B6-E26C-46A1-AA75-A0972E3285E5Q26782948-4B938050-C959-4C53-A2C0-7A111CF05E1FQ26824286-7392F6DF-7EB9-46EF-8018-A4D2B705B2F7Q26850307-39A37FA9-1738-4E7F-866F-FB267B7119ECQ26864726-7A55E8F4-8CFF-4869-B03A-BD5D8488E669Q26865162-12A1E89E-9C0A-4A77-AE99-ED46F90941FFQ26996649-B2AFA205-6CB1-4C31-B3CB-6097DC95931CQ27010675-5B364413-1B2F-4E88-B9CF-B938F211C1FFQ27020947-FBCFE4C4-A039-4371-9F9F-0BAB2F39265CQ27023257-F22CAF6E-2AF2-4EB5-A7BE-417BA499D61CQ27025904-868CD158-6F1A-43ED-AEC8-D26802626792Q27313940-8D7036B0-18F5-4C01-A388-5E74FEA808C6Q27320582-C98023C7-770E-4009-BC26-B0A1452ACE85Q27337360-EC7BD5DE-6550-4632-B573-CE07A5E465D7Q28076827-1ECE8664-E88A-40F5-AE28-B9EB9A49BE70Q28086869-19BDCD65-A378-46BF-A6BC-5084B8D708C5Q28117931-3AA1090F-21D1-4FAD-AC47-FE6C94CB7A7BQ28396707-5FD1E4A1-CD89-4BD2-AAF7-F8194C4416AFQ28506202-3145A9E2-A971-4DE4-B86D-CB0A650189D8Q28551350-8CCFA96A-0ED7-4E5A-86FB-3C12E445ED19Q28567897-D370D04A-F956-444C-9809-7272F3DD6EA0Q28586039-A2858276-9490-414A-8F7C-A833F036E552Q28740448-9D87B2C5-5C4D-419F-8FC3-DE428B037540Q28771393-ED41D1E0-FE09-423E-B038-64C5F53564B3Q28771396-21C264B6-2E27-4C39-9BC8-E755C52DD9F0Q30362378-86DD9449-7F67-4CAE-9BBA-1C571A782FACQ30376422-3E87A2AE-801D-49AB-B461-8A63BE209CFBQ30403591-36C0EBEE-AF2C-4224-8B71-F1D0F815B8C8Q30406616-BED601B7-5E05-4E7C-9100-109B7CBEF177Q30410502-C034C9F1-A59D-4148-AE7C-C253C93FCD54Q30411531-CAA1E9C4-9694-4F37-92BC-2BB56F49A2A0Q30420595-5E851AE6-AD7F-4305-B82D-052F38CD0DA3Q30448778-F59FAEE4-9F79-4E7A-AD14-28A2BBC02885
P2860
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Dysregulation of mTOR signaling in fragile X syndrome.
@en
type
label
Dysregulation of mTOR signaling in fragile X syndrome.
@en
prefLabel
Dysregulation of mTOR signaling in fragile X syndrome.
@en
P2093
P2860
P1476
Dysregulation of mTOR signaling in fragile X syndrome.
@en
P2093
Ali Sharma
Charles A Hoeffer
Eric Klann
R Suzanne Zukin
Sean M McBride
Takahiro Miyawaki
Yukihiro Takayasu
P2860
P304
P356
10.1523/JNEUROSCI.3696-09.2010
P407
P577
2010-01-01T00:00:00Z