Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. - Wikidata - wikimedia - TriplyDB

Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.

Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.

http://www.wikidata.org/entity/Q36879452

about

The arrestin domain-containing 3 protein regulates body mass and energy expenditure Neuroinflammatory responses in diabetic retinopathy New insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancreatic β-cells: the involvement of the Wnt signaling pathway effector β-catenin Insights into obesity and diabetes at the intersection of mouse and human genetics Redox homeostasis in pancreatic β cells Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein Structure of the N-terminal domain of human thioredoxin-interacting protein Transcription factor Ets1 regulates expression of thioredoxin-interacting protein and inhibits insulin secretion in pancreatic β-cells Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cells AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells β-Cell failure in type 2 diabetes.Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death.Adenosine-containing molecules amplify glucose signaling and enhance txnip expression.Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein.Impaired PI3K/Akt signal pathway and hepatocellular injury in high-fat fed rats.The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk.Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity.Glucose controls nuclear accumulation, promoter binding, and transcriptional activity of the MondoA-Mlx heterodimer.Minireview: Thioredoxin-interacting protein: regulation and function in the pancreatic β-cell.Deficiency of thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition.ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity.MicroRNA-200 is induced by thioredoxin-interacting protein and regulates Zeb1 protein signaling and beta cell apoptosis.Crystallization and preliminary X-ray analysis of the N-terminal domain of human thioredoxin-interacting protein.Small-molecule inhibition of inflammatory β-cell death.Thioredoxin regulates adipogenesis through thioredoxin-interacting protein (Txnip) protein stability.Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus.Relationship between thioredoxin-interacting protein (TXNIP) and islet β-cell dysfunction in patients with impaired glucose tolerance and hypertriglyceridemia Akt and PTEN: beta-cell mass and pancreas plasticity.Preventing β-cell loss and diabetes with calcium channel blockers A novel TXNIP-based mechanism for Cx43-mediated regulation of oxidative drug injury Calcium channel blockers act through nuclear factor Y to control transcription of key cardiac genes.Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy.TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity.Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients.Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance.'Metabolically healthy obesity': origins and implications.

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P2860

Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.

http://www.wikidata.org/entity/Q36879452

description

2008 nî lūn-bûn

@nan

2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

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2008年论文

@zh

2008年论文

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name

Thioredoxin-interacting protei ...... and protects against diabetes.

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type

label

Thioredoxin-interacting protei ...... and protects against diabetes.

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prefLabel

Thioredoxin-interacting protei ...... and protects against diabetes.

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Thioredoxin-interacting protei ...... and protects against diabetes.

@en

P2093

Alan D Attie

http://www.w3.org/2001/XMLSchema#string

Anath Shalev

http://www.w3.org/2001/XMLSchema#string

Dawn B Davis

http://www.w3.org/2001/XMLSchema#string

Francesca M Couto

http://www.w3.org/2001/XMLSchema#string

Junqin Chen

http://www.w3.org/2001/XMLSchema#string

Roger A Davis

http://www.w3.org/2001/XMLSchema#string

Simon T Hui

http://www.w3.org/2001/XMLSchema#string

P2860

Positional cloning of the combined hyperlipidemia gene Hyplip1

Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression

Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?

Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis

Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

A possible interaction of thioredoxin with VDUP1 in HeLa cells detected in a yeast two-hybrid system

TXNIP regulates peripheral glucose metabolism in humans.

Life and death of the pancreatic beta cells.

beta-cell apoptosis: stimuli and signaling.

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3581-3594

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10.1096/FJ.08-111690

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10

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22

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Imran N. Mungrue

Aldons Jake Lusis

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2008-06-13T00:00:00Z

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5303184

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18552236

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2537437

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