Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.
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The arrestin domain-containing 3 protein regulates body mass and energy expenditureNeuroinflammatory responses in diabetic retinopathyNew insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancreatic β-cells: the involvement of the Wnt signaling pathway effector β-cateninInsights into obesity and diabetes at the intersection of mouse and human geneticsRedox homeostasis in pancreatic β cellsTxnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout miceThe structural basis for the negative regulation of thioredoxin by thioredoxin-interacting proteinStructure of the N-terminal domain of human thioredoxin-interacting proteinTranscription factor Ets1 regulates expression of thioredoxin-interacting protein and inhibits insulin secretion in pancreatic β-cellsThioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signalingGlucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cellsAMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cellsβ-Cell failure in type 2 diabetes.Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death.Adenosine-containing molecules amplify glucose signaling and enhance txnip expression.Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein.Impaired PI3K/Akt signal pathway and hepatocellular injury in high-fat fed rats.The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk.Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity.Glucose controls nuclear accumulation, promoter binding, and transcriptional activity of the MondoA-Mlx heterodimer.Minireview: Thioredoxin-interacting protein: regulation and function in the pancreatic β-cell.Deficiency of thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition.ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cellsInhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathyDisruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity.MicroRNA-200 is induced by thioredoxin-interacting protein and regulates Zeb1 protein signaling and beta cell apoptosis.Crystallization and preliminary X-ray analysis of the N-terminal domain of human thioredoxin-interacting protein.Small-molecule inhibition of inflammatory β-cell death.Thioredoxin regulates adipogenesis through thioredoxin-interacting protein (Txnip) protein stability.Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus.Relationship between thioredoxin-interacting protein (TXNIP) and islet β-cell dysfunction in patients with impaired glucose tolerance and hypertriglyceridemiaAkt and PTEN: beta-cell mass and pancreas plasticity.Preventing β-cell loss and diabetes with calcium channel blockersA novel TXNIP-based mechanism for Cx43-mediated regulation of oxidative drug injuryCalcium channel blockers act through nuclear factor Y to control transcription of key cardiac genes.Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy.TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity.Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients.Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance.'Metabolically healthy obesity': origins and implications.
P2860
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P2860
Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Thioredoxin-interacting protei ...... and protects against diabetes.
@en
type
label
Thioredoxin-interacting protei ...... and protects against diabetes.
@en
prefLabel
Thioredoxin-interacting protei ...... and protects against diabetes.
@en
P2093
P2860
P356
P1433
P1476
Thioredoxin-interacting protei ...... and protects against diabetes.
@en
P2093
Alan D Attie
Anath Shalev
Dawn B Davis
Francesca M Couto
Junqin Chen
Roger A Davis
Simon T Hui
P2860
P304
P356
10.1096/FJ.08-111690
P407
P577
2008-06-13T00:00:00Z