The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. - Wikidata - wikimedia - TriplyDB

The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1.

The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1.

http://www.wikidata.org/entity/Q36890122

about

ABL tyrosine kinases: evolution of function, regulation, and specificity Abl family kinases regulate endothelial barrier function in vitro and in mice Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse T Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors.The Role of Crk Adaptor Proteins in T-Cell Adhesion and Migration The adaptor protein Crk in immune response Cell biological steps and checkpoints in accessing NK cell cytotoxicity Signaling at neuro/immune synapses Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl Tyrosine kinases EnAbling adaptor molecules for chemokine-induced Rap1 activation in T cells SHEP1 partners with CasL to promote marginal zone B-cell maturation ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration.Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor.Proteomic characterization of plasma membrane-proximal T cell activation responses.Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1 CRK proteins selectively regulate T cell migration into inflamed tissues.HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells.Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease.Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.Regulatory T cells require TCR signaling for their suppressive function Hem-1: putting the "WAVE" into actin polymerization during an immune response.Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1.Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk Abl tyrosine kinases in T-cell signaling Signal transduction during activation and inhibition of natural killer cells.The cellular context of T cell signaling.Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rap1 Modular design of immunological synapses and kinapses.Multiple pathways leading from the T-cell antigen receptor to the actin cytoskeleton network.The insider's guide to leukocyte integrin signalling and function.Building tolerance by dismantling synapses: inhibitory receptor signaling in natural killer cells.Arg kinase regulates epithelial cell polarity by targeting β1-integrin and small GTPase pathways.

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P2860

The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1.

http://www.wikidata.org/entity/Q36890122

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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name

The WAVE2 complex regulates T ...... G-mediated activation of Rap1.

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type

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The WAVE2 complex regulates T ...... G-mediated activation of Rap1.

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prefLabel

The WAVE2 complex regulates T ...... G-mediated activation of Rap1.

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Journal of Cell Biology

P1476

The WAVE2 complex regulates T ...... G-mediated activation of Rap1.

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P2093

Colin M Segovis

http://www.w3.org/2001/XMLSchema#string

Daniel D Billadeau

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Jason S Mitchell

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Jeffrey C Nolz

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Lucas P Nacusi

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Ricardo B Medeiros

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Yoji Shimizu

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P2860

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion

RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas-related docking protein family, and its subsequent binding to the Src homology 2 domain of c-Crk

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity

Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element

c-Abl kinase regulates the protein binding activity of c-Crk

Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway

Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor

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1231-1244

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10.1083/JCB.200801121

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P433

6

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P478

182

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2008-09-01T00:00:00Z

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23272923

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18809728

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2542481

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