Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. - Wikidata - wikimedia - TriplyDB

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

http://www.wikidata.org/entity/Q36892606

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RHO binding to FAM65A regulates Golgi reorientation during cell migration A case report of spinal dural arteriovenous fistula: origins, determinants, and consequences of abnormal vascular malformations.Combined HMG-COA reductase and prenylation inhibition in treatment of CCM.The pathobiology of vascular malformations: insights from human and model organism genetics.Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation.HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver.Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations.Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.The molecular basis of endothelial cell plasticity.The Vascular Wall: a Plastic Hub of Activity in Cardiovascular Homeostasis and Disease.Vascular heterogeneity and specialization in development and disease.Linking Brain Arteriovenous Malformations With Anorectal Hemorrhoids: A Clinical and Anatomical Review.Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.KRIT1 mutations in three Japanese pedigrees with hereditary cavernous malformation.EphB4 forward signalling mediates angiogenesis caused by CCM3/PDCD10-ablation.Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease.Krüppel-like factors and vascular wall homeostasis.Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology.Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex.Endothelial-to-mesenchymal transition in cardiovascular diseases: Developmental signaling pathways gone awry.Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model.Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis.RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.Dysregulated exocytosis of angiopoietin-2 drives cerebral cavernous malformation.Vascular Anomalies Caused by Abnormal Signaling within Endothelial Cells: Targets for Novel Therapies.Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy.A micro-CT-based method for quantitative brain lesion characterization and electrode localization.Gut Microbiome and Endothelial TLR4 Activation Provoke Cerebral Cavernous Malformations.2017 Year in Review and Message from the Editors to Our Reviewers.Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function.Krüppel-like factors: Crippling and un-crippling metabolic pathways.Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

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P2860

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

http://www.wikidata.org/entity/Q36892606

description

2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

@wuu

2016年论文

@zh

2016年论文

@zh-cn

name

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

@en

type

label

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

@en

prefLabel

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

@en

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P1476

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

@en

P2093

Alan T Tang

http://www.w3.org/2001/XMLSchema#string

Alexander C Wright

http://www.w3.org/2001/XMLSchema#string

Dean Y Li

http://www.w3.org/2001/XMLSchema#string

Issam A Awad

http://www.w3.org/2001/XMLSchema#string

Jisheng Yang

http://www.w3.org/2001/XMLSchema#string

Kevin J Whitehead

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Lauren M Goddard

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Mark L Kahn

http://www.w3.org/2001/XMLSchema#string

Robert Shenkar

http://www.w3.org/2001/XMLSchema#string

Su Zhou

http://www.w3.org/2001/XMLSchema#string

P2860

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling.

A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells

Lack of CCM1 induces hypersprouting and impairs response to flow

Structural Insights into the Molecular Recognition between Cerebral Cavernous Malformation 2 and Mitogen-Activated Protein Kinase Kinase Kinase 3

MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions

Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype.

Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth

CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation

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122-126

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10.1038/NATURE17178

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7597

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532

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Xiangjian Zheng

Simon J. Arthur

Sharika Bamezai

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2016-03-30T00:00:00Z

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299499345

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1030169179

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27027284

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4864035

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