Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin.
about
Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs diseaseNeuronal targeting, internalization, and biological activity of a recombinant atoxic derivative of botulinum neurotoxin A.Bone marrow transplantation corrects the enzyme defect in neurons of the central nervous system in a lysosomal storage diseaseTetanus toxin C-fragment: the courier and the cure?Construction of hybrid proteins that migrate retrogradely and transynaptically into the central nervous system.Lysosomal membrane permeability stimulates protein aggregate formation in neurons of a lysosomal diseaseMolecular dissection of botulinum neurotoxin reveals interdomain chaperone function.CuZn superoxide dismutase (SOD-1):tetanus toxin fragment C hybrid protein for targeted delivery of SOD-1 to neuronal cells.A multi-domain protein system based on the HC fragment of tetanus toxin for targeting DNA to neuronal cells.Non-viral neuronal gene delivery mediated by the HC fragment of tetanus toxin.Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis--an approach for slowing Alzheimer disease?Internalization and retrograde axonal trafficking of tetanus toxin in motor neurons and trans-synaptic propagation at central synapses exceed those of its C-terminal-binding fragments.Enhancement of diphtheria toxin potency by replacement of the receptor binding domain with tetanus toxin C-fragment: a potential vector for delivering heterologous proteins to neurons.Production of human beta-hexosaminidase A with highly phosphorylated N-glycans by the overexpression of the Ogataea minuta MNN4 gene.A mouse model for mucopolysaccharidosis type III A (Sanfilippo syndrome).Retargeting of adenoviral vectors to neurons using the Hc fragment of tetanus toxin.Tetanus toxin fragments and Bcl-2 fusion proteins: cytoprotection and retrograde axonal migration.
P2860
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P2860
Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin.
@en
type
label
Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin.
@en
prefLabel
Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin.
@en
P2093
P2860
P356
P1476
Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin.
@en
P2093
K Dobrenis
M C Rattazzi
P2860
P304
P356
10.1073/PNAS.89.6.2297
P407
P577
1992-03-01T00:00:00Z