N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene
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Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activityMolecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein.Multiple SH2-mediated interactions in v-src-transformed cells.A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fpsDistinct and opposite roles for SH2 and SH3 domains of v-src in embryo survival and hemangiosarcoma formation.v-Src suppresses SHPS-1 expression via the Ras-MAP kinase pathway to promote the oncogenic growth of cells.Wild-type and mutant forms of v-src differentially alter neuronal migration and differentiation in vivo.Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.Mutations in the SH3 domain of the src oncogene which decrease association of phosphatidylinositol 3'-kinase activity with pp60v-src and alter cellular morphology.Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.Deletions in the SH2 domain of p60v-src prevent association with the detergent-insoluble cellular matrixMutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformationSequence and functional differences between Schmidt-Ruppin D and Schmidt-Ruppin A strains of pp60v-srcSite-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinasespp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-srcAssociation of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation.Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stabilitySrc homology region 2 domains direct protein-protein interactions in signal transduction.Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene productsDown regulation by p60v-src of genes specifically expressed and developmentally regulated in postmitotic quail neuroretina cellsLysine residues form an integral component of a novel NH2-terminal membrane targeting motif for myristylated pp60v-src.Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of v-src.Enhancement of transforming potential of human insulinlike growth factor 1 receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence.Requirement of phosphatidylinositol-3 kinase modification for its association with p60src.Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.Expression of 9E3 mRNA is associated with mitogenicity, phosphorylation, and morphological alteration in chicken embryo fibroblasts.A glycoprotein in the plasma membrane matrix as a major potential substrate of p60v-src.The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.Phosphatidylinositol kinase activity associates with viral p60src protein.Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein.Recombinants within the tyrosine kinase region of v-abl and v-src identify a v-abl segment that confers lymphoid specificity.Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutantsRole of gag sequence in the biochemical properties and transforming activity of the avian sarcoma virus UR2-encoded gag-ros fusion proteinSuppression of Rous sarcoma virus-induced tumor formation by preinfection with viruses encoding src protein with novel N termini.Modulation of arachidonic acid metabolism by Rous sarcoma virus.DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes.Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters.Biochemical properties of p60v-src mutants that induce different cell transformation parameters.
P2860
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P2860
N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
1985年论文
@zh
1985年论文
@zh-cn
name
N-terminal deletions in Rous s ...... ure with the cellular src gene
@en
type
label
N-terminal deletions in Rous s ...... ure with the cellular src gene
@en
prefLabel
N-terminal deletions in Rous s ...... ure with the cellular src gene
@en
P2093
P2860
P356
P1476
N-terminal deletions in Rous s ...... ure with the cellular src gene
@en
P2093
P2860
P304
P356
10.1128/MCB.5.10.2789
P407
P577
1985-10-01T00:00:00Z