Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells.
about
The Trafficking of the Water Channel Aquaporin-2 in Renal Principal Cells-a Potential Target for Pharmacological Intervention in Cardiovascular DiseasesHow do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5?Ionic imbalance, in addition to molecular crowding, abates cytoskeletal dynamics and vesicle motility during hypertonic stress.AVP-induced increase in AQP2 and p-AQP2 is blunted in heart failure during cardiac remodeling and is associated with decreased AT1R abundance in rat kidneyAngiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expressionA fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2.Sensing, signaling and sorting events in kidney epithelial cell physiology.RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporterHigh-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentrationThe hypertonic environment differentially regulates wild-type CFTR and TNR-CFTR chloride channels.Epithelial sodium channel abundance is decreased by an unfolded protein response induced by hyperosmolalityEffect of volume expansion with hypertonic- and isotonic saline and isotonic glucose on sodium and water transport in the principal cells in the kidneyVasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus.Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts.Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clustersNF-kappaB modulates aquaporin-2 transcription in renal collecting duct principal cells.AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medullaAquaporin-2 abundance in the renal collecting duct: new insights from cultured cell models.NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity.Regulation of the water channel aquaporin-2 by posttranslational modification.Molecular biology of water and salt regulation in the kidney.Dynamic regulation and dysregulation of the water channel aquaporin-2: a common cause of and promising therapeutic target for water balance disorders.Molecular mechanisms regulating aquaporin-2 in kidney collecting duct.The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis.Modulation of aquaporin 2 expression in the kidney of young goats by changes in nitrogen intake.Diabetes Insipidus.Brattleboro rats have impaired apical membrane water permeability regulation in the outer medullary collecting duct principal cells.Acute and chronic metabolic acidosis interferes with aquaporin-2 translocation in the rat kidney collecting ducts.A Single Amino Acid Substitution in the Renal Betaine/GABA Transporter Prevents Trafficking to the Plasma Membrane
P2860
Q26768170-8605549B-BC98-4B46-978A-55D4CFF77F2BQ26770757-DF1A8431-3905-42A5-8B2A-26A64867E64BQ27325433-7639454A-CC76-4C57-9450-CDEA0835811AQ28543216-45E79C5A-5057-4217-889E-07EC33DE5B6AQ28581163-0DFD9989-CDF3-4786-BE2D-49F2D6FC6AEAQ30485052-0CDB5826-3584-4D2C-A820-C3438A7818C2Q33961141-38229B0C-8521-4B1F-91A0-C3BDDF7F5247Q34085234-14D75D83-5DF2-4D05-8DFB-93859D57AAD1Q34295359-16D6C1E9-674F-4176-9C0F-CF5237E3F4DEQ34625411-B7D36E5E-CD96-4C46-AA42-2557B80E8583Q34631876-6A71539F-C6BE-4A83-AE43-6CA3DAA819A5Q34997788-79C1037C-120E-4EFD-871A-10C0A7B5C240Q35149581-9C11C341-CB2F-4B71-9961-EDBC27DF73D5Q35845853-37C199FD-F85A-4355-A064-2F9C7A8F1F34Q36769706-0A257A63-4E84-46A7-96A4-79859BD652C6Q36940474-5AF65BFB-3BFF-404B-9FEA-1AD2E5A4AE1EQ37383377-C310D38A-DEA2-4972-B6E5-B4E0B3B25706Q37401651-B0877C73-E505-4EAB-9C5C-FFE0242AEC55Q37510779-0278F484-55C2-491A-9009-BC2FC7BA41EAQ37838598-E54818BD-D205-406C-A0F6-FE145F4F7836Q37945497-2AB1A469-F138-4BF9-9EFA-96D3B276C163Q38152961-4BA806E7-B1E6-4A57-A0F4-51E5A5B59D75Q38985544-E47C74E8-852C-4EBC-8010-D2E01F676B49Q44172949-54E5D1FD-4CC4-4592-9C7A-F49DB592491DQ45216125-EF3E25CA-233D-47D2-8CFE-7E2BCB750287Q51112288-4FCABA75-AAC3-4BAF-8EDD-FA6B1D5CF82FQ51534368-1B2095CA-F2F6-4622-AB98-E052330F655AQ51758323-6F916E81-FE6B-4CDA-A490-DCA858829491Q58919899-9D9970BA-CECD-4DC3-BE32-275DACFE279E
P2860
Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Acute hypertonicity alters aqu ...... ane of renal epithelial cells.
@en
type
label
Acute hypertonicity alters aqu ...... ane of renal epithelial cells.
@en
prefLabel
Acute hypertonicity alters aqu ...... ane of renal epithelial cells.
@en
P2093
P2860
P356
P1476
Acute hypertonicity alters aqu ...... rane of renal epithelial cells
@en
P2093
Dennis Brown
Hua A J Lu
Richard Bouley
Toshiyuki Matsuzaki
Udo Hasler
P2860
P304
26643-26661
P356
10.1074/JBC.M801071200
P407
P577
2008-07-29T00:00:00Z