Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches.
about
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injuryRapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease.Perispinal etanercept produces rapid improvement in primary progressive aphasia: identification of a novel, rapidly reversible TNF-mediated pathophysiologic mechanismSUMOylation: Novel Neuroprotective Approach for Alzheimer's Disease?APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspectiveInhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged ratsNeuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's diseaseRapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration.Cerebral radiation necrosis.CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activation.The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target.Alzheimer's disease: evidence for the expression of interleukin-33 and its receptor ST2 in the brainCombined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling.Neuroprotective Role of Atractylenolide-I in an In Vitro and In Vivo Model of Parkinson's DiseaseProteomic quantification and site-mapping of S-nitrosylated proteins using isobaric iodoTMT reagentsImplications of gliotransmission for the pharmacotherapy of CNS disorders.Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.Late-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process.Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice.Dysregulation of gene expression in a lysosomal storage disease varies between brain regions implicating unexpected mechanisms of neuropathology.The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanismSwift Acetate Glial Assay (SAGA): an accelerated human ¹³C MRS brain exam for clinical diagnostic use.Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)Amyloid precursor protein mediated changes in intestinal epithelial phenotype in vitro.Neuroinflammation induces glial aromatase expression in the uninjured songbird brainAstrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's diseasePro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia.Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment.Lonicera japonica THUNB. Extract Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses by Suppressing NF-κB Signaling in BV-2 Microglial Cellsβ-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microgliaLovastatin induces neuroprotection by inhibiting inflammatory cytokines in 6-hydroxydopamine treated microglia cellsAstrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD).The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS.Rodent models for Alzheimer's disease drug discovery.Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice.Interleukin-1beta-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activity.Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses.RAGE is a key cellular target for Abeta-induced perturbation in Alzheimer's disease.Intermittent hypoxia from obstructive sleep apnea may cause neuronal impairment and dysfunction in central nervous system: the potential roles played by microglia.
P2860
Q21245237-0964C9ED-C0A4-4506-9C0E-E551D9E965C0Q21261380-DA9DD246-CBCE-4CCE-9172-DDADC6AB7A35Q24652684-FBD33D8B-D156-403A-B97E-B45DBB93D1C7Q26783370-E0DBBB6D-7A58-4C1F-8EA5-BE25425E35EDQ28085213-BEC48AF1-1B8C-4DC2-B8D2-5D5D76B4384EQ28577238-274F5D9E-2028-4B0D-86AA-9587621FEE71Q30054419-ADF474AE-6BCF-4F83-8505-28375F4B5A2EQ30481096-AFC3927F-811E-4E0E-AE8F-AFCFBB959E76Q30686634-8E9A9D67-86B0-42E6-9CD5-59A56B0D859AQ33334431-789D1AC9-44B3-41CB-B9D1-AF46263327BBQ33393902-D8FBA6C1-4B40-4487-9AF5-418D75D36CAAQ33589491-72CE61B1-D74C-4021-9CE2-5DBFB7AECA99Q33654204-62CE4265-5103-45CA-9DDC-B5173726CB40Q33749270-2185A0B9-B2FD-4F8B-A5A4-711F5C089831Q33855707-B8014618-80BA-4C20-9F38-5E6300F1AA10Q33971765-BC28EFC9-8276-4503-8B44-5FE869A50E7CQ34006977-0713EB92-48F1-450E-9E4D-E47D72ED801FQ34020079-F3FD1943-3394-4875-8F0F-88525BA5EE53Q34109073-14DCE29F-5C9D-401D-AC0D-AFCF7406238DQ34189460-455E4BE8-9458-40E2-94F6-89A8C938A980Q34324047-ED55104E-1AB7-4E55-B647-53AC092E5522Q34361280-5DCCB8BF-5FFB-47B3-8674-3D100DDAC347Q35124699-AA1B61C0-F41D-473C-A37D-D0D01EF02819Q35152303-6273A3EC-6217-4F85-A46A-DFD709361AD5Q35172593-C3FA304E-B04F-4145-9A19-46FC6EAC320CQ35202286-D32262F1-5D1B-47C3-86F7-1DB66B91C9EEQ35505131-66903970-8B58-4D0A-ADB6-019447B1C5A2Q35505146-69698235-1A74-4D03-B500-6C031304F231Q35515670-2B3F4A8E-2805-496C-AB3C-41826A646B3DQ35822089-E46807D0-F2DE-4463-8BC1-0E0A61512D23Q35852416-D9EB4FC6-76B3-47B8-9A1C-F0F686680529Q35959336-3044EEB6-0EFD-4947-BC16-D55433016278Q36033271-B96ACB70-A69E-4CAE-BAEC-800403A7DFECQ36040645-8E6BC4B3-79DA-400D-AA90-9EE3C9FB03B8Q36117249-E3712B49-4C59-460A-9F80-3370836FE251Q36790190-D32B3E1B-5FF2-40D4-A302-4DE13000F263Q36808464-3EDAFEC4-63E1-4C88-B070-E7033FEB12DFQ36936307-BF4C95A9-B353-4148-8CE1-5167FB8FEB52Q36942363-84796913-4B37-4CEF-A069-CE207FD3E9FAQ37092265-78471F4B-FE7C-4AE5-AF97-BB3C73D4D52E
P2860
Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Glia proinflammatory cytokine ...... et-based discovery approaches.
@en
type
label
Glia proinflammatory cytokine ...... et-based discovery approaches.
@en
prefLabel
Glia proinflammatory cytokine ...... et-based discovery approaches.
@en
P2093
P1476
Glia proinflammatory cytokine ...... et-based discovery approaches.
@en
P2093
Hantamalala Ralay Ranaivo
Heather A Behanna
Linda J Van Eldik
Wendy L Thompson
P304
P356
10.1016/S0074-7742(07)82015-0
P577
2007-01-01T00:00:00Z