Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design.
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MYST protein acetyltransferase activity requires active site lysine autoacetylationTwo endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levelsRegulation of chromatin by histone modificationsCatalysis and substrate selection by histone/protein lysine acetyltransferasesAcylation of Biomolecules in Prokaryotes: a Widespread Strategy for the Control of Biological Function and Metabolic StressEpigenomics of leukemia: from mechanisms to therapeutic applicationsImplication of posttranslational histone modifications in nucleotide excision repairDesign of small molecule epigenetic modulatorsHistone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferasesMolecular basis for the autoregulation of the protein acetyl transferase Rtt109Structure and Biochemical Characterization of Protein Acetyltransferase from Sulfolobus solfataricusStructure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific AcetylationEpigenetic polypharmacology: from combination therapy to multitargeted drugsComputer-aided Molecular Design of Compounds Targeting Histone Modifying EnzymescAMP-regulated protein lysine acetylases in mycobacteriaAcetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosisModulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivesVirtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitorInhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells.Histone modifying enzymes: structures, mechanisms, and specificities.Writers and readers of histone acetylation: structure, mechanism, and inhibitionThe chromatin remodelling complex B-WICH changes the chromatin structure and recruits histone acetyl-transferases to active rRNA genes.Histone acetyltransferases: Rising ancient counterparts to protein kinases.Molecular modeling study on tunnel behavior in different histone deacetylase isoforms.Specificity and versatility of substrate binding sites in four catalytic domains of human N-terminal acetyltransferases.Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells.Small-molecular modulators of cancer-associated epigenetic mechanisms.MicroRNA-26a induced by hypoxia targets HDAC6 in myogenic differentiation of embryonic stem cells.Mating and memory: an educational primer for use with "epigenetic control of learning and memory in Drosophila by Tip60 HAT action"Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential.KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolism.Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology.Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy.Histone deacetylase modulators provided by Mother Nature.Differential binding modes of the bromodomains of CREB-binding protein (CBP) and p300 with acetylated MyoDActivity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells.Chemical mechanisms of histone lysine and arginine modificationsAlcohol-induced protein hyperacetylation: mechanisms and consequencesMYSTs mark chromatin for chromosomal functions.Discovery and mechanism of natural products as modulators of histone acetylation.
P2860
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P2860
Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Chemistry of acetyl transfer b ...... lications for effector design.
@en
type
label
Chemistry of acetyl transfer b ...... lications for effector design.
@en
prefLabel
Chemistry of acetyl transfer b ...... lications for effector design.
@en
P2860
P356
P1433
P1476
Chemistry of acetyl transfer b ...... lications for effector design.
@en
P2093
Hodawadekar SC
Marmorstein R
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210619
P407
P577
2007-08-01T00:00:00Z