Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin.
about
Pathogenic PS1 phosphorylation at Ser367Central angiotensin II stimulation promotes β amyloid production in Sprague Dawley rats.Dynamic changes of the phosphoproteome in postmortem mouse brains.Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6-Abundant Breast Cancer Cells by Regulating γ-Secretase-Mediated Notch1 Activation in Caveolae.Retinoic acid-elicited RARα/RXRα signaling attenuates Aβ production by directly inhibiting γ-secretase-mediated cleavage of amyloid precursor proteinProstaglandin I2 upregulates the expression of anterior pharynx-defective-1α and anterior pharynx-defective-1β in amyloid precursor protein/presenilin 1 transgenic mice.Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system.Genetic Deletion of Tumor Necrosis Factor-α Attenuates Amyloid-β Production and Decreases Amyloid Plaque Formation and Glial Response in the 5XFAD Model of Alzheimer's Disease.Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.Protein Phosphorylation is a Key Mechanism in Alzheimer's Disease.Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders.G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1.Prostaglandin I2 is responsible for ameliorating prostaglandin E2 stress in stimulating the expression of tumor necrosis factor α in a β-amyloid protein -dependent mechanism.Thiacremonone Potentiates Anti-Oxidant Effects to Improve Memory Dysfunction in an APP/PS1 Transgenic Mice Model.Regulated intramembrane proteolysis: emergent role in cell signalling pathways.Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness.Akt1 phosphorylates Nicastrin to regulate its protein stability and activity.Magnesium Ions Inhibit the Expression of Tumor Necrosis Factor α and the Activity of γ-Secretase in a β-Amyloid Protein-Dependent Mechanism in APP/PS1 Transgenic Mice.
P2860
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P2860
Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Tumor necrosis factor-alpha-el ...... n of presenilin and nicastrin.
@en
type
label
Tumor necrosis factor-alpha-el ...... n of presenilin and nicastrin.
@en
prefLabel
Tumor necrosis factor-alpha-el ...... n of presenilin and nicastrin.
@en
P2093
P2860
P356
P1476
Tumor necrosis factor-alpha-el ...... n of presenilin and nicastrin.
@en
P2093
Bo-Jeng Wang
Lan-Hsin Kuo
Ming-Kuan Hu
Wang-Wei Tsai
Ying-Tsen Tung
Yung-Feng Liao
P2860
P304
P356
10.1091/MBC.E07-09-0987
P577
2008-07-30T00:00:00Z