Dual targeting of the cyclin/Rb/E2F and mitochondrial pathways in mantle cell lymphoma with the translation inhibitor silvestrol.
about
Discovery of Anticancer Agents of Diverse Natural OriginMantle cell lymphoma in the era of precision medicine-diagnosis, biomarkers and therapeutic agentsEmerging links between E2F control and mitochondrial functionTherapeutic potential of the translation inhibitor silvestrol in hepatocellular cancerRocaglamide, silvestrol and structurally related bioactive compounds from Aglaia speciesAn E2F1-HOXB9 transcriptional circuit is associated with breast cancer progression.Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity.The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative diseaseCyclopenta[b]benzofuran and Secodammarane Derivatives from the Stems of Aglaia stellatopilosa.Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributorBioactive flavaglines and other constituents isolated from Aglaia perviridis.Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia.Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex.Flavaglines: potent anticancer drugs that target prohibitins and the helicase eIF4A.Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas.FGFR1-Activated Translation of WNT Pathway Components with Structured 5' UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation
P2860
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P2860
Dual targeting of the cyclin/Rb/E2F and mitochondrial pathways in mantle cell lymphoma with the translation inhibitor silvestrol.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Dual targeting of the cyclin/R ...... nslation inhibitor silvestrol.
@en
type
label
Dual targeting of the cyclin/R ...... nslation inhibitor silvestrol.
@en
prefLabel
Dual targeting of the cyclin/R ...... nslation inhibitor silvestrol.
@en
P2093
P2860
P1476
Dual targeting of the cyclin/R ...... anslation inhibitor silvestrol
@en
P2093
Amy Lehman
Courtney J Prince
David Jarjoura
David M Lucas
Lapo Alinari
Michael R Grever
Rajeswaran Mani
Robert A Baiocchi
Ryan B Edwards
P2860
P304
P356
10.1158/1078-0432.CCR-12-0839
P407
P50
P577
2012-07-12T00:00:00Z