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Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinasesInteraction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cellsA human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1Microinjection of recombinant p21rho induces rapid changes in cell morphologyMulticopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factorsA gain-of-function germline mutation in Drosophila ras1 affects apoptosis and cell fate during developmentRationale for RAS mutation-tailored therapies.Chimeric proteins define variable and essential regions of Ha-ras-encoded protein.Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations.Structure of the carboxyl terminus of the RAS gene-encoded P21 proteins.Identification of a nucleotide exchange-promoting activity for p21ras.Differential activation of yeast adenylyl cyclase by Ras1 and Ras2 depends on the conserved N terminus.Growing and developing Dictyostelium cells express different ras genes.ras-p21-induced cell transformation: unique signal transduction pathways and implications for the design of new chemotherapeutic agents.Synthetic peptides of the Rab effector domain inhibit vesicular transport through the secretory pathway.Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain libraryExpression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastineThe murine N-ras gene is not essential for growth and development.K-ras is an essential gene in the mouse with partial functional overlap with N-ras.The ral gene: a new ras related gene isolated by the use of a synthetic probeExpression of the Aplysia californica rho gene in Escherichia coli: purification and characterization of its encoded p21 productThe role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skinGTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.RAS signalling is abnormal in a c-raf1 MEK1 double mutantTwo types of RAS mutants that dominantly interfere with activators of RAS.A ras effector domain mutant which is temperature sensitive for cellular transformation: interactions with GTPase-activating protein and NF-1Functional interaction between p21rap1A and components of the budding pathway in Saccharomyces cerevisiae.Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins.Transfected human beta-polymerase promoter contains a ras-responsive elementThe bovine papillomavirus E5 oncogene can cooperate with ras: identification of p21 amino acids critical for transformation by c-rasH but not v-rasH.Genetic definition of ras effector elements.H-ras mutants lacking the epitope for the neutralizing monoclonal antibody Y13-259 show decreased biological activity and are deficient in GTPase-activating protein interaction.ras effector loop mutations that dissociate p120GAP and neurofibromin interactions.Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.p21-ras effector domain mutants constructed by "cassette" mutagenesis.Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.Genetic interactions with Rap1 and Ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development.
P2860
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P2860
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Mutational analysis of a ras catalytic domain.
@en
type
label
Mutational analysis of a ras catalytic domain.
@en
prefLabel
Mutational analysis of a ras catalytic domain.
@en
P2093
P2860
P356
P1476
Mutational analysis of a ras catalytic domain.
@en
P2093
Papageorge AG
Willumsen BM
P2860
P304
P356
10.1128/MCB.6.7.2646
P407
P577
1986-07-01T00:00:00Z