In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine. - Wikidata - wikimedia - TriplyDB

In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine.

In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine.

http://www.wikidata.org/entity/Q36925899

about

Sigma receptors as potential therapeutic targets for neuroprotection Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse.Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia Diabetes Accelerates Retinal Neuronal Cell Death In A Mouse Model of Endogenous Hyperhomocysteinemia.The oligomeric states of the purified sigma-1 receptor are stabilized by ligands.Validation of structural and functional lesions of diabetic retinopathy in mice Absence of clinical correlates of diabetic retinopathy in the Ins2Akita retina.Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons.Accelerated retinal ganglion cell death in mice deficient in the Sigma-1 receptor Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseases.Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1).Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells.The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements.Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger.Prediction of diabetic retinopathy: role of oxidative stress and relevance of apoptotic biomarkers.Diabetic Retinopathy: Retina-Specific Methods for Maintenance of Diabetic Rodents and Evaluation of Vascular Histopathology and Molecular Abnormalities.The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.Subcellular localization of the sigma-1 receptor in retinal neurons - an electron microscopy study.Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1 Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathy (+)-Pentazocine Reduces NMDA-Induced Murine Retinal Ganglion Cell Death Through a σR1-Dependent Mechanism MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model Role of Sigma 1 Receptor in Retinal Degeneration of the Ins2Akita/+ Murine Model of Diabetic Retinopathy Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc- in mouse retinal Müller glial cells.Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration.Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse.The pharmacology of sigma-1 receptors.Sigma receptor 1 modulates ER stress and Bcl2 in murine retina.Metal chelator combined with permeability enhancer ameliorates oxidative stress-associated neurodegeneration in rat eyes with elevated intraocular pressure.Neurodegeneration and neuroprotection in diabetic retinopathy.The biology of retinopathy of prematurity: how knowledge of pathogenesis guides treatment.Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment.Principles of Ocular Pharmacology.Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation.The Role of Sigma1R in Mammalian Retina.Peeking into Sigma-1 Receptor Functions Through the Retina.

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P2860

In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine.

http://www.wikidata.org/entity/Q36925899

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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In vivo protection against ret ...... ptor 1 ligand (+)-pentazocine.

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In vivo protection against ret ...... ptor 1 ligand (+)-pentazocine.

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In vivo protection against ret ...... ptor 1 ligand (+)-pentazocine.

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Investigative Ophthalmology & Visual Science

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In vivo protection against ret ...... ptor 1 ligand (+)-pentazocine.

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Barbara Mysona

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Jennifer Duplantier

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Pamela M Martin

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Penny Roon

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Sylvia B Smith

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Ying Dun

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P2860

Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene

Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1)

Purification, molecular cloning, and expression of the mammalian sigma1-binding site

Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2

Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice

Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival

Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina

Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress

Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.

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9

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49

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Vadivel Ganapathy

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5382728

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