Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging
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The effect of deficient muscarinic signaling on commonly reported biochemical effects in schizophrenia and convergence with genetic susceptibility loci in explaining symptom dimensions of psychosis.YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2.Growth Hormone-Releaser Diet Attenuates Cognitive Dysfunction in Klotho Mutant Mice via Insulin-Like Growth Factor-1 Receptor Activation in a Genetic Aging Model.A systems biology approach to identify intelligence quotient score-related genomic regions, and pathways relevant to potential therapeutic treatments.Altered KLOTHO and NF-κB-TNF-α Signaling Are Correlated with Nephrectomy-Induced Cognitive Impairment in Rats.Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential.1,25(OH)2D3 dependent overt hyperactivity phenotype in klotho-hypomorphic mice.Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood.The age-regulating protein klotho is vital to sustain retinal function.A novel role for brain interleukin-6: facilitation of cognitive flexibility in rat orbitofrontal cortex.Interaction of basal forebrain cholinergic neurons with the glucocorticoid system in stress regulation and cognitive impairment.Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway.Klotho regulates CA1 hippocampal synaptic plasticity.Hypoxia preconditioning of mesenchymal stromal cells enhances PC3 cell lymphatic metastasis accompanied by VEGFR-3/CCR7 activation.Neuroprotective Effect of Nanodiamond in Alzheimer's Disease Rat Model: a Pivotal Role for Modulating NF-κB and STAT3 Signaling.Deficit in learning and memory of rats with chronic fluorosis correlates with the decreased expressions of M1 and M3 muscarinic acetylcholine receptors.(E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates LPS-Mediated Memory Impairment by Inhibition of STAT3 Pathway.Klotho, the Key to Healthy Brain Aging?
P2860
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P2860
Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Inactivation of JAK2/STAT3 sig ...... mice, a genetic model of aging
@en
type
label
Inactivation of JAK2/STAT3 sig ...... mice, a genetic model of aging
@en
prefLabel
Inactivation of JAK2/STAT3 sig ...... mice, a genetic model of aging
@en
P2093
P2860
P356
P1476
Inactivation of JAK2/STAT3 sig ...... mice, a genetic model of aging
@en
P2093
Choon-Gon Jang
Eun-Joo Shin
Hyoung-Chun Kim
Jae-Hyung Bach
Ji Hoon Jeong
Seok-Joo Park
Seung-Yeol Nah
Sun Seek Min
Toshitaka Nabeshima
P2860
P2888
P304
P356
10.1038/NPP.2013.39
P407
P577
2013-02-06T00:00:00Z