Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.
about
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stabilityFANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repairStructural peculiarities of the (MHF1-MHF2)4 octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: a solution SAXS studyFANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCLMRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repairPALB2 is an integral component of the BRCA complex required for homologous recombination repairEvidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-linksPALB2 regulates recombinational repair through chromatin association and oligomerizationInteraction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndromeIdentification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair networkHuman RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biologyMolecular pathogenesis and clinical management of Fanconi anemiaSusceptibility pathways in Fanconi's anemia and breast cancerFanconi anemia complementation group A (FANCA) protein has intrinsic affinity for nucleic acids with preference for single-stranded formsHow the fanconi anemia pathway guards the genomeAcetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesisThe Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathwaysCheckpoint signaling from a single DNA interstrand crosslinkManipulation of DNA Repair Proficiency in Mouse Models of Colorectal CancerThe clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancerGenetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell FunctionFunctions and regulation of the multitasking FANCM family of DNA motor proteinsPluripotent stem cells and gene therapyThe Fanconi anemia pathway and DNA interstrand cross-link repairModelling human disease with pluripotent stem cellsMechanism and regulation of incisions during DNA interstrand cross-link repairStructure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair PathwayDefining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasomeThe structure of the FANCM–MHF complex reveals physical features for functional assemblyStructure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage responseEsc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae.RAD51 mutants cause replication defects and chromosomal instabilityPALB2: the hub of a network of tumor suppressors involved in DNA damage responsesFANCI protein binds to DNA and interacts with FANCD2 to recognize branched structuresCellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insightsQuality control mechanisms in cellular and systemic DNA damage responsesUncoupling of transcription and translation of Fanconi anemia (FANC) complex proteins during spermatogenesisMitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
P2860
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P2860
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Emergence of a DNA-damage resp ...... oni anaemia and BRCA proteins.
@en
type
label
Emergence of a DNA-damage resp ...... oni anaemia and BRCA proteins.
@en
prefLabel
Emergence of a DNA-damage resp ...... oni anaemia and BRCA proteins.
@en
P2860
P356
P1476
Emergence of a DNA-damage resp ...... oni anaemia and BRCA proteins.
@en
P2093
Weidong Wang
P2860
P2888
P304
P356
10.1038/NRG2159
P577
2007-09-04T00:00:00Z