Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias. - Wikidata - wikimedia - TriplyDB

Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias.

Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias.

http://www.wikidata.org/entity/Q36936412

about

Reduced expression of Cx43 attenuates ventricular remodeling after myocardial infarction via impaired TGF-beta signaling Gap junctions Computational model of erratic arrhythmias in a cardiac cell network: the role of gap junctions ZP1609/Danegaptide and mitochondrial connexin hemichannels: a harbinger for peptide drug design.Enhanced connexin 43 expression delays intra-mitotic duration and cell cycle traverse independently of gap junction channel function.Phosphatase-resistant gap junctions inhibit pathological remodeling and prevent arrhythmias.Electrophysiological effect of rotigaptide in rabbits with heart failure.Cycle length restitution in sinoatrial node cells: a theory for understanding spontaneous action potential dynamics.Enhancement of ventricular gap-junction coupling by rotigaptide.Connexin43 phosphorylation: structural changes and biological effects.Cx43 CT domain influences infarct size and susceptibility to ventricular tachyarrhythmias in acute myocardial infarction.Optimizing the management of atrial fibrillation: focus on current guidelines and the impact of new agents on future recommendations.Pharmacological modulation of connexin-formed channels in cardiac pathophysiology.Novel molecular targets for atrial fibrillation therapy.Remote conditioning the heart overview: translatability and mechanism.Connexins in the heart.Novel pharmacophores of connexin43 based on the "RXP" series of Cx43-binding peptides A change of heart: heterogeneous remodeling in heart failure.The action of mimetic peptides on connexins protects fibroblasts from the negative effects of ischemia reperfusion The antiarrhythmic dipeptide ZP1609 (danegaptide) when given at reperfusion reduces myocardial infarct size in pigs.Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischaemia/reperfusion independent from mitochondrial connexin 43.Network properties of interstitial cells of Cajal affect intestinal pacemaker activity and motor patterns, according to a mathematical model of weakly coupled oscillators.Role of Non-Myocyte Gap Junctions and Connexin Hemichannels in Cardiovascular Health and Disease: Novel Therapeutic Targets?Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease.

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P2860

Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias.

http://www.wikidata.org/entity/Q36936412

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Pharmacological modulation of ...... for prevention of arrhythmias.

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J.1742-7843.2007.00123.X

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Basic and Clinical Pharmacology and Toxicology

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Pharmacological modulation of ...... for prevention of arrhythmias

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Anne Louise Kjølbye

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James K Hennan

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Jørgen S Petersen

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P2860

Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial

Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43

Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice

Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40

Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study

Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle.

Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123).

Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias.

Functional, structural, and dynamic basis of electrical heterogeneity in healthy and diseased cardiac muscle: implications for arrhythmogenesis and anti-arrhythmic drug therapy.

Pathophysiology and prevention of atrial fibrillation.

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215-230

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10.1111/J.1742-7843.2007.00123.X

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4

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