Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet - Wikidata - wikimedia - TriplyDB

Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet

Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet

http://www.wikidata.org/entity/Q36938197

about

Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function The Macrophage Switch in Obesity Development Linking obesity with type 2 diabetes: the role of T-bet An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation.RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance.The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages.Role of T cells in malnutrition and obesity.Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation Immune regulation of metabolic homeostasis in health and disease.Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5.Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity Plaque Size Is Decreased but M1 Macrophage Polarization and Rupture Related Metalloproteinase Expression Are Maintained after Deleting T-Bet in ApoE Null Mice.Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance Arterial Stiffening in Western Diet-Fed Mice Is Associated with Increased Vascular Elastin, Transforming Growth Factor-β, and Plasma Neuraminidase.Weight cycling increases T-cell accumulation in adipose tissue and impairs systemic glucose tolerance.Targeting oxidized LDL improves insulin sensitivity and immune cell function in obese Rhesus macaques.Obesity accelerates T cell senescence in murine visceral adipose tissue.The immune cell transcription factor T-bet: A novel metabolic regulator.Improved methodologies for the study of adipose biology: insights gained and opportunities ahead.Can metabolically healthy obesity be explained by diet, genetics, and inflammation?Adipose tissue inflammation in the pathogenesis of type 2 diabetes.Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency.Nutritional effects on T-cell immunometabolism.Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.Low alpha-synuclein levels in the blood are associated with insulin resistance.Modulation of Cell-Mediated Immunity to Suppress High Fat Diet-Induced Obesity and Insulin Resistance The impact of type 2 diabetes on the outcome of localized renal cell carcinoma.Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells.Aging, Obesity, and Inflammatory Age-Related Diseases.Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons.Interferon-gamma released from omental adipose tissue of insulin-resistant humans alters adipocyte phenotype and impairs response to insulin and adiponectin release.

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Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet

http://www.wikidata.org/entity/Q36938197

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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Improved insulin sensitivity d ...... ell transcription factor T-bet

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J.CMET.2013.02.019

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Cell Metabolism

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Improved insulin sensitivity d ...... ell transcription factor T-bet

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Chi Teng Vong

http://www.w3.org/2001/XMLSchema#string

Edward T Wargent

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Emilie Stolarczyk

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Esperanza Perucha

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Graham M Lord

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Ian Jackson

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James B Canavan

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Jane K Howard

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Michael A Cawthorne

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Nick Powell

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P2860

A novel transcription factor, T-bet, directs Th1 lineage commitment

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

Obesity is associated with macrophage accumulation in adipose tissue

Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis

Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities

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520-533

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10.1016/J.CMET.2013.02.019

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2013-04-01T00:00:00Z

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236126814

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23562076

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