Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing. - Wikidata - wikimedia - TriplyDB

Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.

Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.

http://www.wikidata.org/entity/Q36938909

about

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts Viable mouse gene ablations that robustly alter brain Aβ levels are rare.An overview of APP processing enzymes and products.Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like.ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1 Structural and mechanistic commonalities of amyloid-β and the prion protein Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.Biochemical identification of a linear cholesterol-binding domain within Alzheimer's β amyloid peptide X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.Cell biology, regulation and inhibition of beta-secretase (BACE-1).Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships?Membrane trafficking pathways in Alzheimer's disease.Phytosterols and Dementia.Consecutive Analysis of BACE1 Function on Developing and Developed Neuronal Cells.Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α.Omega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms Proximity of SCG10 and prion protein in membrane rafts.Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.Microdomain switching is a bad move for APP.Synaptic localization of the SUMOylation-regulating protease SENP5 in the adult mouse brain.The physical approximation of APP and BACE-1: A key event in alzheimer's disease pathogenesis.TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes

P2860

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P2860

Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.

http://www.wikidata.org/entity/Q36938909

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Membrane microdomain switching ...... precursor protein processing.

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type

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Membrane microdomain switching ...... precursor protein processing.

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Membrane microdomain switching ...... precursor protein processing.

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Journal of Cell Biology

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Membrane microdomain switching ...... d precursor protein processing

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P2093

Koji Wada

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Kumi Kaneko

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Misako Okuno

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Nobuyuki Nukina

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Takashi Sakurai

http://www.w3.org/2001/XMLSchema#string

Taku Kashiyama

http://www.w3.org/2001/XMLSchema#string

Takumi Akagi

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Tsutomu Hashikawa

http://www.w3.org/2001/XMLSchema#string

P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.

The amyloid-beta precursor protein: integrating structure with biological function

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission

Crystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid Protein Production

Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

Lipid rafts and signal transduction

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339-352

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scholarly article

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10.1083/JCB.200804075

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2

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183

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Hideaki Shimizu

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2008-10-01T00:00:00Z

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23399692

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18936252

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2568028

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