Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective.
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A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.Structural approaches to understanding retinal proteins needed for visionA functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2Conformational states of the full-length glucagon receptorA dynamic view of molecular switch behavior at serotonin receptors: implications for functional selectivityNullspace Sampling with Holonomic Constraints Reveals Molecular Mechanisms of Protein GαsChemistry and biology of the initial steps in vision: the Friedenwald lecture.Exploring the mechanism of F282L mutation-caused constitutive activity of GPCR by a computational study.Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complexMechanistic insights into the allosteric modulation of opioid receptors by sodium ions.Bacterial chemoreceptor dynamics correlate with activity state and are coupled over long distancesActive-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists.Crystallization scale preparation of a stable GPCR signaling complex between constitutively active rhodopsin and G-protein.Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism.Biased signaling: potential agonist and antagonist of PAR2.Opioid receptors: Structural and mechanistic insights into pharmacology and signaling.Unifying view of mechanical and functional hotspots across class A GPCRs.Crucial role of the orexin-B C-terminus in the induction of OX1 receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis.Universal allosteric mechanism for Gα activation by GPCRs.Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein ActivationEnergetic analysis of the rhodopsin-G-protein complex links the α5 helix to GDP release.Harnessing allostery: a novel approach to drug discovery.Conformational thermostabilisation of corticotropin releasing factor receptor 1.Frustration-guided motion planning reveals conformational transitions in proteins.What can we learn from molecular dynamics simulations for GPCR drug design?In vitro screening of major neurotransmitter systems possibly involved in the mechanism of action of antibodies to S100 protein in released-active form.The future of drug discovery: enabling technologies for enhancing lead characterization and profiling therapeutic potential.Activation processes in ligand-activated G protein-coupled receptors: A case study of the adenosine A2A receptor.Comprehensive analysis of sphingosine-1-phosphate receptor mutants during zebrafish embryogenesis.Tauroursodeoxycholic acid binds to the G-protein site on light activated rhodopsin.The nucleotide-free state of heterotrimeric G proteins α-subunit adopts a highly stable conformation.A conformation-equilibrium model captures ligand-ligand interactions and ligand-biased signalling by G-protein coupled receptors.
P2860
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P2860
Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Conformational flexibility and ...... ein activation: a perspective.
@en
type
label
Conformational flexibility and ...... ein activation: a perspective.
@en
prefLabel
Conformational flexibility and ...... ein activation: a perspective.
@en
P2860
P1476
Conformational flexibility and ...... ein activation: a perspective.
@en
P2093
Heidi E Hamm
P2860
P304
P356
10.1016/J.JMB.2013.04.011
P407
P577
2013-04-16T00:00:00Z