The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration
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Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuriaConformational remodeling of the fibronectin matrix selectively regulates VEGF signaling.The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration.Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment.T cell activation is reduced by the catalytically inactive form of protein tyrosine phosphatase SHP-2SH2 domain-containing protein tyrosine phosphatase 2 and focal adhesion kinase protein interactions regulate pulmonary endothelium barrier function.Expression and clinical significance of tyrosine phosphatase SHP2 in thyroid carcinomaFunctions of Shp2 in cancer.SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer.Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion.New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract.LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells.Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast cancer through the activation of SRC-family kinases.The tyrosine phosphatase SHP2 associates with CUB domain-containing protein-1 (CDCP1), regulating its expression at the cell surface in a phosphorylation-dependent mannerExpression and prognosis value of SHP2 in patients with pancreatic ductal adenocarcinoma.Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions.The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination.Shp2-Mitogen-Activated Protein Kinase Signaling Drives Proliferation during Zebrafish Embryo Caudal Fin Fold Regeneration.The use of SHP-2 gene transduced bone marrow mesenchymal stem cells to promote osteogenic differentiation and bone defect repair in rat.Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition.Cytotoxic activity of Shp2 inhibitor fumosorinone in human cancer cells.
P2860
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P2860
The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration
description
2013 nî lūn-bûn
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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name
The tyrosine phosphatase SHP2 ...... persistence and cell migration
@en
type
label
The tyrosine phosphatase SHP2 ...... persistence and cell migration
@en
prefLabel
The tyrosine phosphatase SHP2 ...... persistence and cell migration
@en
P2093
P2860
P1476
The tyrosine phosphatase SHP2 ...... persistence and cell migration
@en
P2093
Michael D Schaller
Yehenew M Agazie
Zachary R Hartman
P2860
P304
P356
10.1158/1541-7786.MCR-12-0578
P577
2013-03-19T00:00:00Z