Combinatorial ShcA docking interactions support diversity in tissue morphogenesis
about
Evolution of SH2 domains and phosphotyrosine signalling networksThe Gut Microbiota in Immune-Mediated Inflammatory DiseasesThe adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrierTemporal regulation of EGF signalling networks by the scaffold protein Shc1The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.ShcA signalling is essential for tumour progression in mouse models of human breast cancerThe adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis.Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.Mapping protein interactions by combining antibody affinity maturation and mass spectrometry.ErbB signaling in cardiac development and disease.Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions.The role of muscle spindles in the development of the monosynaptic stretch reflexNegative feedback loop between p66Shc and ZEB1 regulates fibrotic EMT response in lung cancer cellsDistinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasisShc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation.Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response.Molecular dynamics simulations reveal that Tyr-317 phosphorylation reduces Shc binding affinity for phosphotyrosyl residues of epidermal growth factor receptorEndothelial Shc regulates arteriogenesis through dual control of arterial specification and inflammation via the notch and nuclear factor-κ-light-chain-enhancer of activated B-cell pathways.The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.Teaching an old dogma new tricks: twenty years of Shc adaptor signalling.The Tyrosine Kinome Dictates Breast Cancer Heterogeneity and Therapeutic Responsiveness.The Erk MAP kinase pathway is activated at muscle spindles and is required for induction of the muscle spindle-specific gene Egr3 by neuregulin1.Downregulated adaptor protein p66(Shc) mitigates autophagy process by low nutrient and enhances apoptotic resistance in human lung adenocarcinoma A549 cells.Shc and the mechanotransduction of cellular anchorage and metastasis.p66Shc couples mechanical signals to RhoA through FAK-dependent recruitment of p115-RhoGEF and GEF-H1.A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation.Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptorThe ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function.Insights into the Shc Family of Adaptor Proteins.ShcA Adaptor Protein Promotes Nephrin Endocytosis and Is Upregulated in Proteinuric Nephropathies.Detachment-Based Equilibrium of Anoikic Cell Death and Autophagic Cell Survival Through Adaptor Protein p66(Shc).The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner.The p66ShcA adaptor protein regulates healing after myocardial infarction.The ShcA SH2 domain engages a 14-3-3/PI3'K signaling complex and promotes breast cancer cell survival.
P2860
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P2860
Combinatorial ShcA docking interactions support diversity in tissue morphogenesis
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Combinatorial ShcA docking interactions support diversity in tissue morphogenesis
@en
type
label
Combinatorial ShcA docking interactions support diversity in tissue morphogenesis
@en
prefLabel
Combinatorial ShcA docking interactions support diversity in tissue morphogenesis
@en
P2093
P2860
P356
P1433
P1476
Combinatorial ShcA docking interactions support diversity in tissue morphogenesis
@en
P2093
Eric Frank
James Fawcett
Jan Kucera
Lingying Li
Tony Pawson
W Rod Hardy
P2860
P304
P356
10.1126/SCIENCE.1140114
P407
P577
2007-07-01T00:00:00Z