Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. - Wikidata - wikimedia - TriplyDB

Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice.

Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice.

http://www.wikidata.org/entity/Q36956106

about

SLC27 fatty acid transport proteins Identification of novel inhibitors of dietary lipid absorption using zebrafish Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis.Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8)NPC1L1 and cholesterol transport Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1.Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis.Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal.Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels.Effects of adiposity on plasma lipid response to reductions in dietary saturated fatty acids and cholesterol.Effects of lipid-lowering drugs on irisin in human subjects in vivo and in human skeletal muscle cells ex vivo.Impact of murine intestinal apolipoprotein A-IV expression on regional lipid absorption, gene expression, and growth Ezetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic Fatty liver disease A pilot study of ezetimibe vs. atorvastatin for improving peripheral microvascular endothelial function in stable patients with type 2 diabetes mellitus.A randomized, double-blind, placebo-controlled study of the effect of ezetimibe on glucose metabolism in subjects with type 2 diabetes mellitus and hypercholesterolemia.Protein mediators of sterol transport across intestinal brush border membrane.Recent advances in small bowel diseases: Part II.Visualization of lipid metabolism in the zebrafish intestine reveals a relationship between NPC1L1-mediated cholesterol uptake and dietary fatty acid.Physiological role of hepatic NPC1L1 in human cholesterol and lipoprotein metabolism: new perspectives and open questions.Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver.Inhibition of intestinal cholesterol absorption decreases atherosclerosis but not adipose tissue inflammation Dietary fat is a lipid source in 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice.Dietary cholesterol effects on adipose tissue inflammation.Role of the gut in lipid homeostasis Acyl chain length, saturation, and hydrophobicity modulate the efficiency of dietary fatty acid absorption in adult humans.Efficacy of combination of Ezetimibe 10 mg and rosuvastatin 2.5 mg versus rosuvastatin 5 mg monotherapy for hypercholesterolemia in patients with type 2 diabetes.Ezetimibe markedly attenuates hepatic cholesterol accumulation and improves liver function in the lysosomal acid lipase-deficient mouse, a model for cholesteryl ester storage disease.Transporters as drug targets: discovery and development of NPC1L1 inhibitors.Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport.New insights into the molecular mechanism of intestinal fatty acid absorption.Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis.Intestinal and hepatic niemann-pick c1-like 1.Lipid-lowering therapies, glucose control and incident diabetes: evidence, mechanisms and clinical implications.Therapeutic effects of ezetimibe for non-alcoholic steatohepatitis in fatty liver shionogi-ob/ob mice.Quantitation of the rates of hepatic and intestinal cholesterol synthesis in lysosomal acid lipase-deficient mice before and during treatment with ezetimibe.Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux Ezetimibe ameliorates intestinal chylomicron overproduction and improves glucose tolerance in a diet-induced hamster model of insulin resistance.Fatty acids modulate the expression levels of key proteins for cholesterol absorption in Caco-2 monolayer.Ezetimibe prevents hepatic steatosis induced by a high-fat but not a high-fructose diet.

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P2860

Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice.

http://www.wikidata.org/entity/Q36956106

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2008 nî lūn-bûn

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2008年论文

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Reduced absorption of saturate ...... be-treated and Npc1l1-/- mice.

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Reduced absorption of saturate ...... be-treated and Npc1l1-/- mice.

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Reduced absorption of saturate ...... be-treated and Npc1l1-/- mice.

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AJPGI.90275.2008

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American Journal of Physiology - Gastrointestinal and Liver Physiology

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Reduced absorption of saturate ...... be-treated and Npc1l1-/- mice.

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David Y Hui

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Dean E Gilham

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Eric D Labonté

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Joanna P Davies

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Juan C Rojas

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Lisa M Camarota

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Patrick Tso

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Philip N Howles

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Ronald J Jandacek

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Yiannis A Ioannou

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P2860

A family of fatty acid transporters conserved from mycobacterium to man

Identification of the major intestinal fatty acid transport protein

Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects

Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4

Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice

Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function

Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts

Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

Characterization of the putative native and recombinant rat sterol transporter Niemann-Pick C1 Like 1 (NPC1L1) protein

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