Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA).
about
Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome BrainHuman cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replicationThe crystal structure of an 'All Locked' nucleic acid duplexA regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplexSynthesis and biophysical properties of C5-functionalized LNA (locked nucleic acid).C5-alkynyl-functionalized α-L-LNA: synthesis, thermal denaturation experiments and enzymatic stabilityFunctionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.Structure and dynamics of the HIV-1 frameshift element RNABrain-specific knockdown of miR-29 results in neuronal cell death and ataxia in mice.Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues.Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia modelMapping targetable sites on human telomerase RNA pseudoknot/template domain using 2'-OMe RNA-interacting polynucleotide (RIPtide) microarrays.Biology by design: from top to bottom and backN,3'-cyclo-5'-O-Cyano-methyl-thymidine.A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia8-Oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves.High-affinity DNA targeting using readily accessible mimics of N2'-functionalized 2'-amino-α-L-LNA.Synthesis and antiviral properties of spirocyclic [1,2,3]-triazolooxazine nucleosides.Short antisense-locked nucleic acids (all-LNAs) correct alternative splicing abnormalities in myotonic dystrophy.Nonconventional chemical inhibitors of microRNA: therapeutic scope.Selection of LNA-containing DNA aptamers against recombinant human CD73.Chemistry of nucleic acids: impacts in multiple fields.Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides.LNA-based oligonucleotide electrotransfer for miRNA inhibition.Fluorescent intercalator displacement replacement (FIDR) assay: determination of relative thermodynamic and kinetic parameters in triplex formation--a case study using triplex-forming LNAsPyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): tools for fundamental research, diagnostics, and nanotechnology.Sub-cellular temporal and spatial distribution of electrotransferred LNA/DNA oligomerA self-assembling short oligonucleotide duplex suitable for pretargetingDNA strands with alternating incorporations of LNA and 2'-O-(pyren-1-yl)methyluridine: SNP-discriminating RNA detection probes.Effect of locked-nucleic acid on a biologically active g-quadruplex. A structure-activity relationship of the thrombin aptamerDelivery of RNAi-Based Oligonucleotides by ElectropermeabilizationCu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry.CHO microRNA engineering is growing up: recent successes and future challenges.Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides.Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNAExploring the role of chirality in nucleic acid recognition.Antisense drug discovery and development.Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals.Locked nucleic acid based beacons for surface interaction studies and biosensor developmentLocked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA.
P2860
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P2860
Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA).
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA).
@en
type
label
Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA).
@en
prefLabel
Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA).
@en
P2093
P356
P1433
P1476
Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA).
@en
P2093
B Ravindra Babu
Harleen Kaur
Souvik Maiti
P304
P356
10.1021/CR050266U
P577
2007-10-18T00:00:00Z