Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.
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The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tetheringVirological and cellular roles of the transcriptional coactivator LEDGF/p75Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityEmbryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient MiceDNA minicircles clarify the specific role of DNA structure on retroviral integrationCrystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding siteStructural and Histone Binding Ability Characterizations of Human PWWP DomainsStructural basis for high-affinity binding of LEDGF PWWP to mononucleosomesNucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domainNuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domainHRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.The SET complex acts as a barrier to autointegration of HIV-1LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.SUMOylation of the lens epithelium-derived growth factor/p75 attenuates its transcriptional activity on the heat shock protein 27 promoter.Unperturbed posttranscriptional regulatory Rev protein function and HIV-1 replication in astrocytesMolecular mechanisms of retroviral integration site selection.Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing.Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.Retroviral integrase proteins and HIV-1 DNA integrationTOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replicationHIV-1 IN/Pol recruits LEDGF/p75 into viral particlesChromatin organization at the nuclear pore favours HIV replicationRepair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference.DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase SelectivityRole of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targetingPSIP1/LEDGF: a new gene likely involved in sensorineural progressive hearing loss.Sites of retroviral DNA integration: From basic research to clinical applicationsThe Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Subunit of the Capsid-recruited Pre-messenger RNA Cleavage Factor I (CFIm) Complex Mediates HIV-1 Integration into Genes.Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo.In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer.Mind the methyl: methyllysine binding proteins in epigenetic regulation.Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration.LEDGF (p75) promotes DNA-end resection and homologous recombination.HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin.Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells.Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase.Implication of serine residues 271, 273, and 275 in the human immunodeficiency virus type 1 cofactor activity of lens epithelium-derived growth factor/p75.Blocking the interaction between HIV-1 integrase and human LEDGF/p75: mutational studies, virtual screening and molecular dynamics simulations.HIV-1 integrase inhibition: looking at cofactor interactions.
P2860
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P2860
Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Identification and characteriz ...... ency virus type 1 infectivity.
@en
type
label
Identification and characteriz ...... ency virus type 1 infectivity.
@en
prefLabel
Identification and characteriz ...... ency virus type 1 infectivity.
@en
P2093
P2860
P356
P1433
P1476
Identification and characteriz ...... iency virus type 1 infectivity
@en
P2093
Alan Engelman
Francesca Di Nunzio
Janet E Daigle
Judy Lieberman
Ming-Chieh Shun
Yaïr Botbol
P2860
P304
11555-11567
P356
10.1128/JVI.01561-08
P407
P50
P577
2008-09-17T00:00:00Z