Total synthesis and evaluation of [Psi[CH2NH]Tpg4]vancomycin aglycon: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding.
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A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteriaCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisEngineering vascularized tissues using natural and synthetic small moleculesEnzymatic glycosylation of vancomycin aglycon: completion of a total synthesis of vancomycin and N- and C-terminus substituent effects of the aglycon substrateTotal synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization.Vancomycin analogs: Seeking improved binding of d-Ala-d-Ala and d-Ala-d-Lac peptides by side-chain and backbone modifications.Host-guest chemistry of the peptidoglycanTotal synthesis of [Ψ[C(═NH)NH]Tpg(4)]vancomycin and its (4-chlorobiphenyl)methyl derivative: impact of peripheral modifications on vancomycin analogues redesigned for dual D-Ala-D-Ala and D-Ala-D-Lac binding.Synthesis and evaluation of selected key methyl ether derivatives of vancomycin aglycon.The evolving role of chemical synthesis in antibacterial drug discovery.Total syntheses and initial evaluation of [Ψ[C(═S)NH]Tpg⁴]vancomycin, [Ψ[C(═NH)NH]Tpg⁴]vancomycin, [Ψ[CH₂NH]Tpg⁴]vancomycin, and their (4-chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptideSynthesis and stereochemical determination of complestatin A and B (neuroprotectin A and B)Total synthesis of [Ψ[C(═S)NH]Tpg4]vancomycin aglycon, [Ψ[C(═NH)NH]Tpg4]vancomycin aglycon, and related key compounds: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding.Messenger functions of the bacterial cell wall-derived muropeptides.Redesign of glycopeptide antibiotics: back to the futureSilver(I)-promoted conversion of thioamides to amidines: divergent synthesis of a key series of vancomycin aglycon residue 4 amidines that clarify binding behavior to model ligandsCatalytic site-selective thiocarbonylations and deoxygenations of vancomycin reveal hydroxyl-dependent conformational effects.A stepwise dechlorination/cross-coupling strategy to diversify the vancomycin 'in-chloride'.A Pd(0)-mediated indole (macro)cyclization reaction.Studies toward the total synthesis of ristocetin A aglycone using arene-ruthenium complexes as S(N)Ar substrates: Construction of an advanced tricyclic intermediateProbing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues.Investigation into the functional impact of the vancomycin C-ring aryl chlorideVancomycin resistance: modeling backbone variants with D-Ala-D-Ala and D-Ala-D-Lac peptides.Recent advances in the chemistry and biology of naturally occurring antibiotics.Synthesis and evaluation of vancomycin aglycon analogues that bear modifications in the N-terminal D-leucyl amino acid.Total synthesis of chloropeptin II (complestatin) and chloropeptin I.Probing the biology of natural products: molecular editing by diverted total synthesis.Recent advances in the synthesis of new glycopeptide antibiotics.Combating multidrug-resistant bacteria: current strategies for the discovery of novel antibacterials.Industrial natural product chemistry for drug discovery and development.The structural modification of natural products for novel drug discovery.Total Syntheses of Vancomycin-Related Glycopeptide Antibiotics and Key Analogues.Applications of Nonenzymatic Catalysts to the Alteration of Natural Products.Peripheral modifications of [Ψ[CH2NH]Tpg4]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics.Tackling vancomycin-resistant bacteria with 'lipophilic-vancomycin-carbohydrate conjugates'.Binaphthyl-based dicationic peptoids with therapeutic potential.Glycopeptide antibiotic analogs efficient against vancomycin-resistant bacteria: a patent evaluation (WO2013022763).The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.Developments in Glycopeptide Antibiotics.Natural Products as Platforms To Overcome Antibiotic Resistance.
P2860
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P2860
Total synthesis and evaluation of [Psi[CH2NH]Tpg4]vancomycin aglycon: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Total synthesis and evaluation ...... D-Ala and D-Ala-D-Lac binding.
@en
type
label
Total synthesis and evaluation ...... D-Ala and D-Ala-D-Lac binding.
@en
prefLabel
Total synthesis and evaluation ...... D-Ala and D-Ala-D-Lac binding.
@en
P2860
P356
P1476
Total synthesis and evaluation ...... D-Ala and D-Ala-D-Lac binding.
@en
P2093
Brendan M Crowley
Dale L Boger
P2860
P304
P356
10.1021/JA0572912
P407
P577
2006-03-01T00:00:00Z