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Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies

Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies

http://www.wikidata.org/entity/Q36988173

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The primary cilium as a cellular signaling center: lessons from disease The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies Human mutations affect the epigenetic/bookmarking function of HNF1B The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression The exocyst and regulatory GTPases in urinary exosomes.A metabolomics approach using juvenile cystic mice to identify urinary biomarkers and altered pathways in polycystic kidney disease Polycystic liver diseases.microRNA biomarkers in cystic diseases.Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment.Naturally occurring osmolytes modulate the nanomechanical properties of polycystic kidney disease domains The fate of bone marrow-derived cells carrying a Polycystic Kidney Disease mutation in the genetically normal kidney Kidney: polycystic kidney disease.Ectopic expression of cadherin 8 is sufficient to cause cyst formation in a novel 3D collagen matrix renal tubule culture Congenital hepatic fibrosis in autosomal recessive polycystic kidney disease.Epigenetic silencing of the MUPCDH gene as a possible prognostic biomarker for cyst growth in ADPKD.Ouabain Enhances ADPKD Cell Apoptosis via the Intrinsic Pathway.Analysis of the REJ Module of Polycystin-1 Using Molecular Modeling and Force-Spectroscopy Techniques A role for microRNA in cystic liver and kidney diseases.Planar cell polarity in kidney development and disease.Mouse models of polycystic kidney disease induced by defects of ciliary proteins Genome-wide methylation profiling of ADPKD identified epigenetically regulated genes associated with renal cyst development.On the Many Actions of Ouabain: Pro-Cystogenic Effects in Autosomal Dominant Polycystic Kidney Disease.cAMP-dependent chloride secretion mediates tubule enlargement and cyst formation by cultured mammalian collecting duct cells.Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD).N-myc downstream-regulated gene 1 is involved in the regulation of cystogenesis in transgenic mice overexpressing human PKD2 gene.

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Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies

http://www.wikidata.org/entity/Q36988173

description

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2008年论文

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2008年论文

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2008年论文

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name

Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies

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Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies

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Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies

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Cellular and Molecular Life Sciences

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Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies

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N Bukanov

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O Ibraghimov-Beskrovnaya

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Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1

Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel

Polycystin-2 is an intracellular calcium release channel

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm

The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation

PKD1 interacts with PKD2 through a probable coiled-coil domain

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10.1007/S00018-007-7362-X

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4

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17975706

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autosomal dominant polycystic kidney disease

autosomal dominant polycystic kidney

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