Structure-based discovery of antagonists of nuclear receptor LRH-1. - Wikidata - wikimedia - TriplyDB

Structure-based discovery of antagonists of nuclear receptor LRH-1.

Structure-based discovery of antagonists of nuclear receptor LRH-1.

http://www.wikidata.org/entity/Q37000608

about

Insights into Orphan Nuclear Receptors as Prognostic Markers and Novel Therapeutic Targets for Breast Cancer Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation Ligand pose and orientational sampling in molecular docking The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner.Nuclear receptors and pathogenesis of pancreatic cancer.Antiproliferation activity of a small molecule repressor of liver receptor homolog 1 Structure-based virtual screening for drug discovery: principles, applications and recent advances.Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression Liver receptor homolog-1 (LRH-1): a potential therapeutic target for cancer Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket.Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.Liver receptor homolog 1 influences blastocyst hatching in pigs The characterization of an intestine-like genomic signature maintained during Barrett's-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival.LRH1 as a driving factor in pancreatic cancer growth Exploring the molecular basis for selective binding of homoserine dehydrogenase from Mycobacterium leprae TN toward inhibitors: a virtual screening study Why does the gut synthesize glucocorticoids?Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development SERBP1 Is a Component of the Liver Receptor Homologue-1 Transcriptional Complex.Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcription and associated T-cell effector functions.NR5A2 discovering compounds that block tumor growth in PDAC.Human sperm liver receptor homolog-1 (LRH-1) acts as a downstream target of the estrogen signaling pathway.Nuclear receptor NR5A2 controls neural stem cell fate decisions during development.LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness.Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1

P2860

Q26795488-015CB2DE-101F-4B60-8C5D-73853F685C3C Q27728159-3F439157-DECE-4F8D-86C0-A6B32C51305E Q28533958-E638E8AA-3865-4B83-9305-126D6E9D0D0C Q28539752-59DA5423-5749-436A-9574-39A0A5046C1D Q28553211-2FC466A1-9666-4787-8464-05FB48D88593 Q30316110-5254AFFC-8EF2-446B-B677-29DC66FA5C4C Q34168476-34DF77A5-2BAA-4AD0-A39C-9025CF8F7DF2 Q34946775-EE4CB6C8-BFA4-44EB-BB7D-150B1434BA9F Q35282223-7891F089-2B27-4B6A-BCB2-B89C28D58797 Q35484712-8FD4259E-A48D-4243-B4EF-278F5F3096C6 Q36213555-CB7E6D1D-F36C-4361-BEE0-025860CCCA3A Q36296659-0B474A0B-6922-4B03-B1D4-019626456B14 Q36466200-D2F5AE14-FE7A-45E5-B99A-5AA3CEFD1AB7 Q37034076-BBFF7388-90FE-45E0-9893-C9580910805F Q37227732-7A8EB75A-BE05-4E7B-BE0C-1A9B53CE77AA Q37623867-1ED5463F-33EB-4B90-AEF9-D8A8EE16CC4C Q37645108-88B25592-B181-4665-83DF-369B54A291E4 Q38231636-E25ACBB3-8381-42F5-9AC3-317497AECDEA Q38291493-B59DED41-67F3-440F-BE82-1DF43939F31C Q38442006-748CE53B-2EF9-4BF0-9993-C3890DC768DF Q38838638-6621ACF6-54A6-4CF2-84A5-5C8AE2B9205A Q39264548-7932A96F-EF00-4937-B03D-55BAB66E33ED Q40661617-E4687258-3761-4C61-9E33-DFE7D997401D Q42032252-AF72D7CB-2B6C-4AA7-BC0F-B79F43FAB268 Q47403498-7119EADC-F6FD-4A83-9D58-87E0BDBF5321 Q57822497-71550D1F-D635-4D1D-89AA-A783B5FBCAA6

P2860

Structure-based discovery of antagonists of nuclear receptor LRH-1.

http://www.wikidata.org/entity/Q37000608

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 10 May 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Structure-based discovery of antagonists of nuclear receptor LRH-1.

@en

Structure-based discovery of antagonists of nuclear receptor LRH-1.

@nl

type

label

Structure-based discovery of antagonists of nuclear receptor LRH-1.

@en

Structure-based discovery of antagonists of nuclear receptor LRH-1.

@nl

prefLabel

Structure-based discovery of antagonists of nuclear receptor LRH-1.

@en

Structure-based discovery of antagonists of nuclear receptor LRH-1.

@nl

P1433

Q37000608-2E659E07-2364-4A6A-9FE0-BE938D4AFAAD

P1476

Q37000608-BE351069-FEF3-4F28-81BA-310DA5857DDE

P2093

Q37000608-45871D76-5708-4C06-8629-5DE80010161D

Q37000608-56FD68CB-DCC2-445E-92D5-A5B8728393D7

Q37000608-636EF717-0EC7-41B3-B2FF-D6F9FB8B53FF

Q37000608-8BCAE48D-0A6F-4AF7-9790-821485F5391D

Q37000608-992B05B2-4A8A-4D28-808C-FFA194422A42

Q37000608-FF890E78-E078-4ABC-BD59-9BCD5645A8D9

P2860

Q37000608-013DE704-CEF5-49A8-907B-569BEF6B5882

Q37000608-014F1280-D37D-45FB-A623-DF35060398BB

Q37000608-05743E5E-F6C8-4ABE-9B6C-A49774B64245

Q37000608-091EFDF0-8A5B-4DE4-9C2A-BCC3602158E5

Q37000608-0BD54920-2207-4C38-91A4-8C1E331A89A0

Q37000608-0CE88A00-367A-44A9-B7D6-2263ADAA5650

Q37000608-0F161AF1-E3BC-496F-BFD6-6AA2BE4AC583

Q37000608-1568F979-000D-4BE7-A3FC-631E953D0F2C

Q37000608-1DF6CC49-05A5-4DDE-9508-9C1E78A31FA9

Q37000608-1E82F4C4-8ADD-4CC1-85D7-6D34848333DF

P304

Q37000608-6B381132-300B-443B-8AA0-2C1043C001FB

P31

Q37000608-E7075B88-08E6-43C7-AA7E-C903747DF016

P356

Q37000608-5E55797A-9C69-453E-B91F-D9A29B5D028B

P407

Q37000608-AA6D5A1E-762E-4415-AB9F-6E427ED8390C

P433

Q37000608-1B8B4A08-F8CD-44D7-883F-C06A2A5FE09B

P478

Q37000608-4C7661B5-F8B2-480B-AF27-B88B1B8114EB

P50

Q37000608-402466CD-8A0C-402A-8426-034CF675221A

Q37000608-7E131C54-C454-40D0-9F88-C2742BD43374

Q37000608-C2BE4397-D632-4135-8EF0-DCE415FB0A65

P577

Q37000608-5F7C4BEA-154E-4894-BD4B-9A22AF7ECCAD

P698

Q37000608-9955391F-D84E-4ABE-8D29-9958B8BDA36E

P932

Q37000608-FE23B0FE-66C3-4EB9-B484-01735E3A6BA4

P356

JBC.M112.411686

P1433

Journal of Biological Chemistry

P1476

Structure-based discovery of antagonists of nuclear receptor LRH-1.

@en

P2093

Allison K Doak

http://www.w3.org/2001/XMLSchema#string

Cindy Benod

http://www.w3.org/2001/XMLSchema#string

Elena P Sablin

http://www.w3.org/2001/XMLSchema#string

Peter Hwang

http://www.w3.org/2001/XMLSchema#string

Robert J Fletterick

http://www.w3.org/2001/XMLSchema#string

Rubatharshini Uthayaruban

http://www.w3.org/2001/XMLSchema#string

P2860

Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene

The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor

Hierarchical docking of databases of multiple ligand conformations

Flexible ligand docking using conformational ensembles

Structural insights into the mode of action of a pure antiestrogen

Structure-based discovery of a novel, noncovalent inhibitor of AmpC beta-lactamase

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1

ZINC--a free database of commercially available compounds for virtual screening

Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)

P304

19830-19844

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M112.411686

http://www.w3.org/2001/XMLSchema#string

P407

P433

27

http://www.w3.org/2001/XMLSchema#string

P478

288

http://www.w3.org/2001/XMLSchema#string

P50

Brian K. Shoichet

P577

2013-05-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

23667258

http://www.w3.org/2001/XMLSchema#string

P932

3707686

http://www.w3.org/2001/XMLSchema#string