Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5 - Wikidata - wikimedia - TriplyDB

Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5

Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5

http://www.wikidata.org/entity/Q37003502

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Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2)Generation and characterisation of mice deficient in the multi-GTPase domain containing protein, GIMAP8 The immune system GTPase GIMAP6 interacts with the Atg8 homologue GABARAPL2 and is recruited to autophagosomes Gimap3 regulates tissue-specific mitochondrial DNA segregation Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice.Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells.BB rat Gimap gene expression in sorted lymphoid T and B cells TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5).GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes.Innate inflammation in type 1 diabetes Gene-expression signatures differ between different clinical forms of familial hemophagocytic lymphohistiocytosis Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria.CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells Sequence variation and expression of the Gimap gene family in the BB rat.Gimap and T cells: a matter of life or death.GIMAP Proteins in T-Lymphocytes.GTP-dependent scaffold formation in the GTPase of Immunity Associated Protein family.Resisting viral infection: the gene by gene approach.Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice.Cell Death Inducing Microbial Protein Phosphatase Inhibitors--Mechanisms of Action.Quantitative Proteomics of Gut-Derived Th1 and Th1/Th17 Clones Reveal the Presence of CD28+ NKG2D- Th1 Cytotoxic CD4+ T cells GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo.Purification, crystallization and preliminary X-ray analysis of human GIMAP2.Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia.The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein.Gimap3: A foot-in-the-door to tissue-specific regulation of mitochondrial DNA genetics.Tubulin- and actin-associating GIMAP4 is required for IFN-γ secretion during Th cell differentiation.GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation.Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology.Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes.GIMAP6 is required for T cell maintenance and efficient autophagy in mice.Comparison of the Effects of Early Pregnancy with Human Interferon, Alpha 2 (IFNA2), on Gene Expression in Bovine Endometrium1

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Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5

http://www.wikidata.org/entity/Q37003502

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 16 September 2008

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Impaired survival of periphera ...... failure in mice lacking Gimap5

@en

Impaired survival of periphera ...... ailure in mice lacking Gimap5.

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type

label

Impaired survival of periphera ...... failure in mice lacking Gimap5

@en

Impaired survival of periphera ...... ailure in mice lacking Gimap5.

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prefLabel

Impaired survival of periphera ...... failure in mice lacking Gimap5

@en

Impaired survival of periphera ...... ailure in mice lacking Gimap5.

@nl

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BLOOD-2008-03-146555

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Impaired survival of periphera ...... failure in mice lacking Gimap5

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Ake Lernmark

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Brandon Edwards

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Calvin B Williams

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Demin Wang

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Dipica Haribhai

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Edward J Kerschen

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Haiyan Chu

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Hartmut Weiler

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Jack Gorski

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Martin J Hessner

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P2860

IAN family critically regulates survival and development of T lymphocytes.

The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus

Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis

Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36

GIMAP5 regulates mitochondrial integrity from a distinct subcellular compartment

Deficiencies in gut NK cell number and function precede diabetes onset in BB rats

Loss of a gimap/ian gene leads to activation of NF-kappaB through a MAPK-dependent pathway

Ian4 is required for mitochondrial integrity and T cell survival

Evidence for the extrathymic origin of intestinal TCRgammadelta(+) T cells in normal rats and for an impairment of this differentiation pathway in BB rats

Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats

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4905-4914

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10.1182/BLOOD-2008-03-146555

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