Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction
about
Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processesEffect of procysteine on aging-associated changes in hepatic GSH and SMase: evidence for transcriptional regulation of smpd3Gli1 mediates lung cancer cell proliferation and Sonic Hedgehog-dependent mesenchymal cell activation.Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDLInhibition of cyclin-dependent kinase 6 suppresses cell proliferation and enhances radiation sensitivity in medulloblastoma cellsATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation.Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis.The utility of hedgehog signaling pathway inhibition for cancer.Sonic hedgehog signaling in Basal cell nevus syndrome.Basal cell naevus syndrome: an update on genetics and treatment.SULF1/SULF2 reactivation during liver damage and tumour growth.Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures.The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions.P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest.Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer
P2860
Q27022944-F94BC873-DD3F-4916-AC8B-B17B74F0F895Q34238645-830A3AA9-4DAB-4214-83EB-A079F7EAE501Q34718073-CDA9A824-61C0-4E4E-95B3-74CE80192EAEQ35024497-B06E5E33-E7AD-4775-9744-B6651A186AC8Q36377759-EC3C1493-9778-4657-9B28-F671A9107A88Q36843326-1DAB6275-F441-4663-84E7-134CF463CF15Q36926998-5E0768AE-A4C6-42C7-A23D-C4784EAD9C34Q38031211-079026CD-4A93-49C6-84A6-F63E694FD841Q38244794-84C1C8F0-0AF2-4FF8-9606-BDE2F2F8F2B5Q38593322-6F22988E-1BC8-4A33-A17B-1D98C2F5F581Q38783242-9B1144C2-D678-465A-85B7-B854CFB48FCEQ38804205-E8A4AA27-2C4D-4EC1-8571-F32208BFCF23Q39252478-027A13CC-6EA9-414C-A9A4-5D3B08CE8AB5Q41491918-3404222B-DF35-4AA4-BFE8-737E40858C3FQ43189320-00F415F7-7C73-402D-BDE2-20B28878DC9DQ50043839-08D6087C-01C2-4474-82DC-EA5C5169B223Q57962903-9996136C-A02A-453D-8A2B-549B194F5155
P2860
Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 March 2012
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Off-target function of the Son ...... myelinase 2/ceramide induction
@en
Off-target function of the Son ...... yelinase 2/ceramide induction.
@nl
type
label
Off-target function of the Son ...... myelinase 2/ceramide induction
@en
Off-target function of the Son ...... yelinase 2/ceramide induction.
@nl
prefLabel
Off-target function of the Son ...... myelinase 2/ceramide induction
@en
Off-target function of the Son ...... yelinase 2/ceramide induction.
@nl
P2093
P2860
P50
P1476
Off-target function of the Son ...... myelinase 2/ceramide induction
@en
P2093
Besim Ogretmen
Christopher J Clarke
Jacqueline M Kraveka
Jocelyn A Lewis
Marisa Meyers-Needham
Michael Nishimura
Monzur Murshed
R David Sentelle
Sahar A Saddoughi
Salih Gencer
P2860
P304
P356
10.1158/1535-7163.MCT-11-0705
P577
2012-03-27T00:00:00Z