Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort. - Wikidata - wikimedia - TriplyDB

Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort.

Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort.

http://www.wikidata.org/entity/Q37006537

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Examining the pathogenesis of breast cancer using a novel agent-based model of mammary ductal epithelium dynamics A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk.Tumor protein p53 (TP53) testing and Li-Fraumeni syndrome : current status of clinical applications and future directions.Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes.Prevalence of germline TP53 mutations in HER2+ breast cancer patients.Contralateral risk-reducing mastectomy: review of risk factors and risk-reducing strategies.Lobular breast cancer: incidence and genetic and non-genetic risk factors.Mutant p53 - Heat Shock Response Oncogenic Cooperation: A New Mechanism of Cancer Cell Survival.Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification.Primed for cancer: Li Fraumeni Syndrome and the pre-cancerous niche Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promote Mammary Tumorigenesis.Li Fraumeni syndrome, cancer and senescence: a new hypothesis.Tumour morphology of early-onset breast cancers predicts breast cancer risk for first-degree relatives: the Australian Breast Cancer Family Registry.Breast cancer in the young: role of the geneticist Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families.Syndrome-Associated Tumors by Organ System.Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours.The effect of epigenetic silencing and TP53 mutation on the expression of DLL4 in human cancer stem disorder ErbB2 inhibition by lapatinib promotes degradation of mutant p53 protein in cancer cells.A gain-of-function mutant p53-HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress.The 2013 Society of Surgical Oncology Susan G. Komen for the Cure Symposium: MRI in breast cancer: where are we now?Next-generation sequencing for inherited breast cancer risk: counseling through the complexity.Li-Fraumeni syndrome: cancer risk assessment and clinical management.Germline TP53 mutations and the changing landscape of Li-Fraumeni syndrome.Hereditary breast cancer syndromes and genetic testing.Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells.Next generation sequencing is informing phenotype: a TP53 example.Li-Fraumeni syndrome: a paradigm for the understanding of hereditary cancer predisposition.The role of screening MRI in the era of next generation sequencing and moderate-risk genetic mutations.The breast cancer immunophenotype of TP53-p.R337H carriers is different from that observed among other pathogenic TP53 mutation carriers.Somatic TP53 variants frequently confound germ-line testing results.Genes with mutation significance were highly associated with the clinical pattern of patients with breast cancer.Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells-a novel mechanism for the obesity-breast cancer link.Clinical implications of germline mutations in breast cancer: TP53.Cancer risk assessment using genetic panel testing: considerations for clinical application.Genetic testing in a cohort of young patients with HER2-amplified breast cancer.

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Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort.

http://www.wikidata.org/entity/Q37006537

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bilimsel makale

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scientific article published on 04 March 2012

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Breast cancer phenotype in wom ...... ni syndrome consortium effort.

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Breast cancer phenotype in wom ...... ni syndrome consortium effort.

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S10549-012-1993-9

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Breast Cancer Research and Treatment

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Breast cancer phenotype in wom ...... ni syndrome consortium effort.

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Alexandra Lebensohn

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David Euhus

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Deborah A Dillon

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Judith Balmana

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Judy E Garber

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Melinda Telli

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Michelle Rath

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Serena Masciari

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Stephen B Gruber

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Stephen M Pochebit

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P2860

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

Repeated observation of breast tumor subtypes in independent gene expression data sets

The distinctive nature of HER2-positive breast cancers

Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer risk

A cancer family syndrome in twenty-four kindreds.

Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?

Li-Fraumeni syndrome--a molecular and clinical review.

Population-based estimate of the contribution of TP53 mutations to subgroups of early-onset breast cancer: Australian Breast Cancer Family Study.

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s10549-012-1993-9

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Jeffrey N Weitzel

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