2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer. - Wikidata - wikimedia - TriplyDB

2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer.

2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer.

http://www.wikidata.org/entity/Q37010557

about

Redox-directed cancer therapeutics: molecular mechanisms and opportunities STX140, but not paclitaxel, inhibits mammary tumour initiation and progression in C3(1)/SV40 T/t-antigen transgenic mice Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability.Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies.Sulphamoylated 2-methoxyestradiol analogues induce apoptosis in adenocarcinoma cell lines.Inhibition of KIT-glycosylation by 2-deoxyglucose abrogates KIT-signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor.Frequent gene products and molecular pathways altered in prostate cancer- and metastasis-initiating cells and their progenies and novel promising multitargeted therapies.In vitro effects of 2-methoxyestradiol-bis-sulphamate on reactive oxygen species and possible apoptosis induction in a breast adenocarcinoma cell line.Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol.Anticancer agents that counteract tumor glycolysis.Emerging metabolic targets in the therapy of hematological malignancies.Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.2-methoxyestradiol in the pathophysiology of endometriosis: focus on angiogenesis and therapeutic potential.The in vitro effects of 2-methoxyestradiol-bis-sulphamate on cell numbers, membrane integrity and cell morphology, and the possible induction of apoptosis and autophagy in a non-tumorigenic breast epithelial cell line.A theoretical quantitative model for evolution of cancer chemotherapy resistance Synergistic Anticancer Action of Lysosomal Membrane Permeabilization and Glycolysis Inhibition.2-Methoxyoestradiol inhibits glucose transport in rodent skeletal muscle.In vitro effects of an in silico-modelled 17β-estradiol derivative in combination with dichloroacetic acid on MCF-7 and MCF-12A cells.Preservation of the 3D Phenotype Upon Dispersal of Cultured Cell Spheroids Into Monolayer Cultures.

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2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer.

http://www.wikidata.org/entity/Q37010557

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2008 nî lūn-bûn

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2008年学术文章

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2008年學術文章

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2-Methoxyoestradiol-3,17-O,O-b ...... or breast and prostate cancer.

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British Journal of Cancer

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2-Methoxyoestradiol-3,17-O,O-b ...... or breast and prostate cancer.

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P2093

A Purohit

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B V L Potter

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M J Reed

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P2860

Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death

2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity

Multidrug resistance in cancer: role of ATP-dependent transporters

Microtubule targeting agents: basic mechanisms of multidrug resistance (MDR).

In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol.

The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers.

Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents.

A comparison of two orally bioavailable anti-cancer agents, IRC-110160 and STX140.

A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer.

STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells.

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1842-1848

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10.1038/SJ.BJC.6604752

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23452300

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18985042

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