Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.
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Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivoGeneration and initial characterization of FDD knock in miceAberrant protein structure and diseases of the brain.The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutantIschemic brain injury in cerebral amyloid angiopathyImmunomodulation targeting abnormal protein conformation reduces pathology in a mouse model of Alzheimer's disease.Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathiesModeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficitsA human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo.Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) OligomersProteomic characterization of a mouse model of familial Danish dementia.Lessons from a Rare Familial Dementia: Amyloid and Beyond.Neurobiology of rodent self-grooming and its value for translational neuroscienceIncreased AβPP processing in familial Danish dementia patients.Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia.KSGal6ST is essential for the 6-sulfation of galactose within keratan sulfate in early postnatal brain.Animal models of human amyloidoses: are transgenic mice worth the time and trouble?Cerebral amyloid angiopathy: a systematic reviewBRICHOS domain associated with lung fibrosis, dementia and cancer--a chaperone that prevents amyloid fibril formation?Sulfated glycosaminoglycans in protein aggregation diseases.Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice.Amyloid and intracellular accumulation of BRI2.
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Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 April 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cerebral amyloid angiopathy an ...... ish mutant form of human BRI2.
@en
Cerebral amyloid angiopathy an ...... ish mutant form of human BRI2.
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type
label
Cerebral amyloid angiopathy an ...... ish mutant form of human BRI2.
@en
Cerebral amyloid angiopathy an ...... ish mutant form of human BRI2.
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prefLabel
Cerebral amyloid angiopathy an ...... ish mutant form of human BRI2.
@en
Cerebral amyloid angiopathy an ...... ish mutant form of human BRI2.
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P2093
P2860
P1433
P1476
Cerebral amyloid angiopathy an ...... ish mutant form of human BRI2.
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P2093
Ana G Barbeito
Bernardino Ghetti
Leticia Miravalle
Ruben Vidal
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P356
10.1111/J.1750-3639.2008.00164.X
P577
2008-04-10T00:00:00Z