Conformational landscapes of DNA polymerase I and mutator derivatives establish fidelity checkpoints for nucleotide insertion.
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Shedding light on protein folding, structural and functional dynamics by single molecule studiesThe Closing Mechanism of DNA Polymerase I at Atomic ResolutionMolecular dynamics study of the opening mechanism for DNA polymerase IStructural Insights into DNA Replication without Hydrogen BondsDNA Polymerase Conformational Dynamics and the Role of Fidelity-Conferring Residues: Insights from Computational SimulationsOptimized delivery of fluorescently labeled proteins in live bacteria using electroporationSingle-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter.Internalization and observation of fluorescent biomolecules in living microorganisms via electroporation.Characterization of organic fluorophores for in vivo FRET studies based on electroporated molecules.Camera-based single-molecule FRET detection with improved time resolution.Label-free optical detection of single enzyme-reactant reactions and associated conformational changesThe expanded genetic alphabet.Prechemistry nucleotide selection checkpoints in the reaction pathway of DNA polymerase I and roles of glu710 and tyr766.Studying DNA-protein interactions with single-molecule Förster resonance energy transfer.Studying the organization of DNA repair by single-cell and single-molecule imaging.Polymerase/DNA interactions and enzymatic activity: multi-parameter analysis with electro-switchable biosurfaces.Multidomain structure and correlated dynamics determined by self-consistent FRET networks.Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter RNA.Steric gate residues of Y-family DNA polymerases DinB and pol kappa are crucial for dNTP-induced conformational change.Real-time single-molecule studies of the motions of DNA polymerase fingers illuminate DNA synthesis mechanismsProcessive Incorporation of Deoxynucleoside Triphosphate Analogs by Single-Molecule DNA Polymerase I (Klenow Fragment) Nanocircuits.A single-molecule FRET sensor for monitoring DNA synthesis in real time.Active Site Interactions Impact Phosphoryl Transfer during Replication of Damaged and Undamaged DNA by Escherichia coli DNA Polymerase I.Single-molecule FRET reveals proofreading complexes in the large fragment of Bacillus stearothermophilus DNA polymerase I.Protein design: from computer models to artificial intelligenceI260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity
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Conformational landscapes of DNA polymerase I and mutator derivatives establish fidelity checkpoints for nucleotide insertion.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on January 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Conformational landscapes of D ...... ints for nucleotide insertion.
@en
Conformational landscapes of D ...... ints for nucleotide insertion.
@nl
type
label
Conformational landscapes of D ...... ints for nucleotide insertion.
@en
Conformational landscapes of D ...... ints for nucleotide insertion.
@nl
prefLabel
Conformational landscapes of D ...... ints for nucleotide insertion.
@en
Conformational landscapes of D ...... ints for nucleotide insertion.
@nl
P2093
P2860
P356
P1476
Conformational landscapes of D ...... oints for nucleotide insertion
@en
P2093
Achillefs N Kapanidis
Catherine M Joyce
Johannes Hohlbein
Louise Aigrain
Nigel D F Grindley
Olga Potapova
Oya Bermek
Pouya Shoolizadeh
P2860
P2888
P356
10.1038/NCOMMS3131
P407
P577
2013-01-01T00:00:00Z