Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. - Wikidata - wikimedia - TriplyDB

Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.

Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.

http://www.wikidata.org/entity/Q37026223

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TRP channel Ca(2+) sparklets: fundamental signals underlying endothelium-dependent hyperpolarization Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice Dynamic visualization of calcium-dependent signaling in cellular microdomains TACTIC: Trans-Agency Consortium for Trauma-Induced Coagulopathy The role of epoxyeicosatrienoic acids in the cardiovascular system Expression of phosphoinositide-specific phospholipase C isoforms in native endothelial cells Acetylcholine released by endothelial cells facilitates flow-mediated dilatation Aging-related alterations in eNOS and nNOS responsiveness and smooth muscle reactivity of murine basilar arteries are modulated by apocynin and phosphorylation of myosin phosphatase targeting subunit-1 Gain-of-function mutation in TRPV4 identified in patients with osteonecrosis of the femoral head Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators.Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.Integration and Modulation of Intercellular Signaling Underlying Blood Flow Control The myoendothelial junction: connections that deliver the message.Regulation of cellular communication by signaling microdomains in the blood vessel wall.Optical recording reveals novel properties of GSK1016790A-induced vanilloid transient receptor potential channel TRPV4 activity in primary human endothelial cells.Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone Coordination of intercellular Ca(2+) signaling in endothelial cell tubes of mouse resistance arteries.Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle Traumatic brain injury disrupts cerebrovascular tone through endothelial inducible nitric oxide synthase expression and nitric oxide gain of function AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.Functional Tuning of Intrinsic Endothelial Ca2+ Dynamics in Swine Coronary Arteries.The puzzle of TRPV4 channelopathies.Vasodilator responses to acetylcholine are not mediated by the activation of soluble guanylate cyclase or TRPV4 channels in the rat.Calcineurin/nuclear factor of activated T cells-coupled vanilliod transient receptor potential channel 4 ca2+ sparklets stimulate airway smooth muscle cell proliferation Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca²⁺-activated K⁺ channels and smooth muscle Ca²⁺ sparks Protection of coronary endothelial function during cardiac surgery: potential of targeting endothelial ion channels in cardioprotection Ovariectomy-induced reductions in endothelial SK3 channel activity and endothelium-dependent vasorelaxation in murine mesenteric arteries.Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats Primary cilia signaling mediates intraocular pressure sensation.Positive feedback regulation of agonist-stimulated endothelial Ca2+ dynamics by KCa3.1 channels in mouse mesenteric arteries.Upregulation of SK3 and IK1 channels contributes to the enhanced endothelial calcium signaling and the preserved coronary relaxation in obese Zucker rats.Angiotensin II induces membrane trafficking of natively expressed transient receptor potential vanilloid type 4 channels in hypothalamic 4B cells Vascular TRP channels: performing under pressure and going with the flow Optogenetic sensors and effectors: CHROMus-the Cornell Heart Lung Blood Institute Resource for Optogenetic Mouse Signaling.Cell biology. Superresolution subspace signaling.Selective activation of KCa3.1 and CRAC channels by P2Y2 receptors promotes Ca(2+) signaling, store refilling and migration of rat microglial cells The effects of hypertension on the cerebral circulation.Activation of endothelial transient receptor potential C3 channel is required for small conductance calcium-activated potassium channel activation and sustained endothelial hyperpolarization and vasodilation of cerebral artery.

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Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.

http://www.wikidata.org/entity/Q37026223

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on May 2012

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.

@en

Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.

@nl

type

label

Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.

@en

Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.

@nl

prefLabel

Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.

@en

Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.

@nl

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SCIENCE.1216283

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Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function

@en

P2093

Adrian D Bonev

http://www.w3.org/2001/XMLSchema#string

David C Hill-Eubanks

http://www.w3.org/2001/XMLSchema#string

Michael I Kotlikoff

http://www.w3.org/2001/XMLSchema#string

Swapnil K Sonkusare

http://www.w3.org/2001/XMLSchema#string

Thomas J Heppner

http://www.w3.org/2001/XMLSchema#string

Wolfgang Liedtke

http://www.w3.org/2001/XMLSchema#string

P2860

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

Recording single-channel activity of inositol trisphosphate receptors in intact cells with a microscope, not a patch clamp.

Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections

Arterial response to shear stress critically depends on endothelial TRPV4 expression.

NO: the primary EDRF.

Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4

TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress.

The vanilloid transient receptor potential channel TRPV4: from structure to disease.

Endothelial potassium channels, endothelium-dependent hyperpolarization and the regulation of vascular tone in health and disease.

Arachidonic acid cascade in endothelial pathobiology.

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597-601

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scholarly article

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10.1126/SCIENCE.1216283

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6081

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336

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Jonathan Ledoux

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2012-05-01T00:00:00Z

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22556255

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3715993

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