The cardiac persistent sodium current: an appealing therapeutic target?
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The role of late I Na in development of cardiac arrhythmiasLate Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial FibrillationThe persistent sodium current blocker riluzole is antiarrhythmic and anti-ischaemic in a pig model of acute myocardial infarctionIdentifying tinnitus-related genes based on a side-effect network analysis.Synergetic action of domain II and IV underlies persistent current generation in Nav1.3 as revealed by a tarantula toxin.Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re-evaluation of an established drug.Contributions of ion channel currents to ventricular action potential changes and induction of early afterdepolarizations during acute hypoxia.Sodium channel biophysics, late sodium current and genetic arrhythmic syndromesEffects of tetrodotoxin on the mammalian cardiovascular systemRiluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current.Ranolazine: a new approach to treating an old problem.Resveratrol attenuates the Na(+)-dependent intracellular Ca(2+) overload by inhibiting H(2)O(2)-induced increase in late sodium current in ventricular myocytesHuman Na(v)1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons.Sodium-activated potassium channels are functionally coupled to persistent sodium currents.Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: a possible basis for modulation of excitability in vivo.Reduced Na(+) and higher K(+) channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/- mice.Antagonism of Nav channels and α1-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine.Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium.Regulation of intracellular and mitochondrial sodium in health and disease.F 15845 inhibits persistent sodium current in the heart and prevents angina in animal modelsThe arrhythmogenic consequences of increasing late INa in the cardiomyocyte.Tolterodine reduces veratridine-augmented late INa, reverse-INCX and early afterdepolarizations in isolated rabbit ventricular myocytes.In silico assessment of drug safety in human heart applied to late sodium current blockersSodium channel blockers for neuropathic pain.Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations.Ranolazine: an antianginal drug with antiarrhythmic properties.Redox control of cardiac excitability.Advances in targeting voltage-gated sodium channels with small molecules.Late sodium current inhibition in acquired and inherited ventricular (dys)function and arrhythmias.Organs-on-a-chip: a new tool for drug discovery.Diverse mechanisms underlying the regulation of ion channels by carbon monoxide.Multiple targets for flecainide action: implications for cardiac arrhythmogenesis.Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations.Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current.Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart.Persistent (current) in the face of adversity ... a new class of cardiac anti-ischaemic compounds on the horizon?F 15845, a new blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery.A TTX-sensitive resting Na+ permeability contributes to the catecholaminergic automatic activity in rat pulmonary vein.Riluzole reduces arrhythmias and myocardial damage induced by coronary occlusion in anaesthetized pigs.Contribution of the late sodium current to intracellular sodium and calcium overload in rabbit ventricular myocytes treated by anemone toxin.
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The cardiac persistent sodium current: an appealing therapeutic target?
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 10 December 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The cardiac persistent sodium current: an appealing therapeutic target?
@en
The cardiac persistent sodium current: an appealing therapeutic target?
@nl
type
label
The cardiac persistent sodium current: an appealing therapeutic target?
@en
The cardiac persistent sodium current: an appealing therapeutic target?
@nl
prefLabel
The cardiac persistent sodium current: an appealing therapeutic target?
@en
The cardiac persistent sodium current: an appealing therapeutic target?
@nl
P2860
P356
P1476
The cardiac persistent sodium current: an appealing therapeutic target?
@en
P2093
P2860
P304
P356
10.1038/SJ.BJP.0707492
P407
P577
2007-12-10T00:00:00Z