Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. - Wikidata - wikimedia - TriplyDB

Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.

Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.

http://www.wikidata.org/entity/Q37029878

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Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro.Short and Long Term Behavioral and Pathological Changes in a Novel Rodent Model of Repetitive Mild Traumatic Brain Injury Propofol directly increases tau phosphorylation Intermediate filament-associated cytolinker plectin 1c destabilizes microtubules in keratinocytes Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.Considerations for Experimental Animal Models of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy-These Matters Matter.Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3β activation in young mice Anesthetic isoflurane increases phosphorylated tau levels mediated by caspase activation and Aβ generation.Alzheimer's disease and anesthesia.Isoflurane increases neuronal cell death vulnerability by downregulating miR-214.Perioperative cognitive decline in the aging population.Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity.Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.Anesthesia, surgery, illness and Alzheimer's disease Anesthetic effects in Alzheimer transgenic mouse models.Intranasal Insulin Prevents Anesthesia-Induced Spatial Learning and Memory Deficit in Mice Anesthesia Exposure and Risk of Dementia and Alzheimer's Disease: A Prospective Study.Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease Anesthesia and tau pathology.The neuroinflammatory response of postoperative cognitive decline Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation.Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease.Lasting impact of general anaesthesia on the brain: mechanisms and relevance.Does Anesthesia Cause Postoperative Cognitive Decline?Insights into plant consciousness from neuroscience, physics and mathematics: a role for quasicrystals?Anesthetic Alterations of Collective Terahertz Oscillations in Tubulin Correlate with Clinical Potency: Implications for Anesthetic Action and Post-Operative Cognitive Dysfunction.Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.Halothane increases neuronal cell death vulnerability by downregulating miR-214 and upregulating Bax.Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model.The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.Anesthesia and Alzheimer's disease: time to wake up!Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.Microtubule destruction induces tau liberation and its subsequent phosphorylation.What mechanisms of tau protein transport could be responsible for the inverted tau concentration gradient in degenerating axons?Simulating tubulin-associated unit transport in an axon: using bootstrapping for estimating confidence intervals of best-fit parameter values obtained from indirect experimental data.Improving Perioperative Outcomes Through Minimally Invasive and Non-invasive Hemodynamic Monitoring Techniques.Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy.

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Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.

http://www.wikidata.org/entity/Q37029878

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2008年學術文章

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name

Anesthesia-induced hyperphosph ...... cting their stability in vivo.

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Anesthesia-induced hyperphosph ...... cting their stability in vivo.

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type

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Anesthesia-induced hyperphosph ...... cting their stability in vivo.

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Anesthesia-induced hyperphosph ...... cting their stability in vivo.

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Anesthesia-induced hyperphosph ...... cting their stability in vivo.

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Anesthesia-induced hyperphosph ...... cting their stability in vivo.

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JNEUROSCI.4101-08.2008

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Journal of Neuroscience

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Anesthesia-induced hyperphosph ...... cting their stability in vivo.

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P2093

Akihiko Takashima

http://www.w3.org/2001/XMLSchema#string

Alexis Bretteville

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Asok Kumar

http://www.w3.org/2001/XMLSchema#string

Emmanuel Planel

http://www.w3.org/2001/XMLSchema#string

Helen Y Figueroa

http://www.w3.org/2001/XMLSchema#string

Karen E Duff

http://www.w3.org/2001/XMLSchema#string

Li Liu

http://www.w3.org/2001/XMLSchema#string

Mathieu Herman

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Pavan Krishnamurthy

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Peter Davies

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P2860

Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules

Tau protein binds to microtubules through a flexible array of distributed weak sites

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

High resolution two-dimensional electrophoresis of proteins

Microtubule polymerization dynamics

Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules

Perioperative heat balance.

Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders.

Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.

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12798-12807

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scholarly article

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10.1523/JNEUROSCI.4101-08.2008

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48

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28

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2008-11-01T00:00:00Z

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19036972

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2610528

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