Protein kinase PKR mediates the apoptosis induction and growth restriction phenotypes of C protein-deficient measles virus. - Wikidata - wikimedia - TriplyDB

Protein kinase PKR mediates the apoptosis induction and growth restriction phenotypes of C protein-deficient measles virus.

Protein kinase PKR mediates the apoptosis induction and growth restriction phenotypes of C protein-deficient measles virus.

http://www.wikidata.org/entity/Q37033277

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Enhancement of replication of RNA viruses by ADAR1 via RNA editing and inhibition of RNA-activated protein kinase RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replication MicroRNA-sensitive oncolytic measles viruses for cancer-specific vector tropism Mechanisms of protein kinase PKR-mediated amplification of beta interferon induction by C protein-deficient measles virus Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150)Induction of stress granules by interferon and down-regulation by the cellular RNA adenosine deaminase ADAR1.Tipping the balance: antagonism of PKR kinase and ADAR1 deaminase functions by virus gene products.Interplay between innate immunity and negative-strand RNA viruses: towards a rational model Engineered measles virus Edmonston strain used as a novel oncolytic viral system against human hepatoblastoma.A recombinant measles virus unable to antagonize STAT1 function cannot control inflammation and is attenuated in rhesus monkeys.Antagonism of innate immunity by paramyxovirus accessory proteins.Envelope-chimeric entry-targeted measles virus escapes neutralization and achieves oncolysis.Adenosine deaminase acting on RNA 1 (ADAR1) suppresses the induction of interferon by measles virus.Protein kinase PKR catalytic activity is required for the PKR-dependent activation of mitogen-activated protein kinases and amplification of interferon beta induction following virus infection.Measles Virus Defective Interfering RNAs Are Generated Frequently and Early in the Absence of C Protein and Can Be Destabilized by Adenosine Deaminase Acting on RNA-1-Like Hypermutations.Protein kinase PKR amplification of interferon β induction occurs through initiation factor eIF-2α-mediated translational control Control of the induction of type I interferon by Peste des petits ruminants virus.Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1 Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses RNA-dependent protein kinase PKR and the Z-DNA binding orthologue PKZ differ in their capacity to mediate initiation factor eIF2α-dependent inhibition of protein synthesis and virus-induced stress granule formation.The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.N-terminally truncated C protein, CNDelta25, of human parainfluenza virus type 3 is a potent inhibitor of viral replication.Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.Use of attenuated paramyxoviruses for cancer therapy.Activation of the Antiviral Kinase PKR and Viral Countermeasures.A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR).The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication.The measles virus phosphoprotein interacts with the linker domain of STAT1.Apoptosis induced by mammalian reovirus is beta interferon (IFN) independent and enhanced by IFN regulatory factor 3- and NF-κB-dependent expression of Noxa.Measles virus C protein interferes with Beta interferon transcription in the nucleus.Canine distemper virus selectively inhibits apoptosis progression in infected immune cells.Modulation of apoptosis by V protein mumps virus.Inflammasome antagonism by human parainfluenza virus type 3 C protein.Upon Infection the Cellular WD Repeat-containing Protein 5 (WDR5) Localizes to Cytoplasmic Inclusion Bodies and Enhances Measles Virus Replication.Hemagglutinin-specific neutralization of subacute sclerosing panencephalitis viruses.

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P2860

Protein kinase PKR mediates the apoptosis induction and growth restriction phenotypes of C protein-deficient measles virus.

http://www.wikidata.org/entity/Q37033277

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

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2008年學術文章

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name

Protein kinase PKR mediates th ...... otein-deficient measles virus.

@en

Protein kinase PKR mediates th ...... otein-deficient measles virus.

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type

label

Protein kinase PKR mediates th ...... otein-deficient measles virus.

@en

Protein kinase PKR mediates th ...... otein-deficient measles virus.

@nl

prefLabel

Protein kinase PKR mediates th ...... otein-deficient measles virus.

@en

Protein kinase PKR mediates th ...... otein-deficient measles virus.

@nl

P1433

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Journal of Virology

P1476

Protein kinase PKR mediates th ...... otein-deficient measles virus.

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P2093

Ann M Toth

http://www.w3.org/2001/XMLSchema#string

Charles E Samuel

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Patricia Devaux

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P2860

STAT2 is a primary target for measles virus V protein-mediated alpha/beta interferon signaling inhibition

Antiviral actions of interferons

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter

Mechanism of interferon action: identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinase

The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

Nonstructural C protein is required for efficient measles virus replication in human peripheral blood cells.

Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway

Stringent requirement for the C protein of wild-type measles virus for growth both in vitro and in macaques.

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB

P304

961-968

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10.1128/JVI.01669-08

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P407

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2

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83

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Roberto Cattaneo

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2008-11-12T00:00:00Z

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19004947

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P921

apoptotic process

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2612345

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