Molecular mechanisms of the conjugated alpha,beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases.
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Electrophilic affibodies forming covalent bonds to protein targetsMolecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistryThe TRPA1 channel in migraine mechanism and treatmentRedox-dependent anti-inflammatory signaling actions of unsaturated fatty acidsA possible role of acrolein in diabetic retinopathy: involvement of a VEGF/TGFβ signaling pathway of the retinal pigment epithelium in hyperglycemiaReactions of electrophiles with nucleophilic thiolate sites: relevance to pathophysiological mechanisms and remediationProbing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexaneExposure of the U.S. population to acrylamide in the National Health and Nutrition Examination Survey 2003-2004Molecular mechanisms of aldehyde toxicity: a chemical perspective.Gamma-diketone axonopathy: analyses of cytoskeletal motors and highways in CNS myelinated axonsPathological aspects of lipid peroxidation.The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.β-dicarbonyl enolates: a new class of neuroprotectants.A 3-hydroxy β-end group in xanthophylls is preferentially oxidized to a 3-oxo ε-end group in mammals.Signaling actions of electrophiles: anti-inflammatory therapeutic candidatesRole of the Nrf2-ARE pathway in acrylamide neurotoxicity.Molecular mechanism of glyceraldehyde-3-phosphate dehydrogenase inactivation by α,β-unsaturated carbonyl derivativesProtein conjugated with aldehydes derived from lipid peroxidation as an independent parameter of the carbonyl stress in the kidney damage.Interactions of glutathione transferases with 4-hydroxynonenal.Application of the Hard and Soft, Acids and Bases (HSAB) theory to toxicant--target interactions.Formation and signaling actions of electrophilic lipidsN-terminal valine adduct from the anti-HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo.Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease prevention4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte culturesUnilateral microinjection of acrolein into thoracic spinal cord produces acute and chronic injury and functional deficits.Enolate-Forming Phloretin Pharmacophores: Hepatoprotection in an Experimental Model of Drug-Induced Toxicity.Protective properties of 2-acetylcyclopentanone in a mouse model of acetaminophen hepatotoxicity.Determination of urine 3-HPMA, a stable acrolein metabolite in a rat model of spinal cord injuryJoint toxic effects of the type-2 alkene electrophiles.Synaptosomal toxicity and nucleophilic targets of 4-hydroxy-2-nonenalNew insights into mechanisms of gamma-diketone-induced axonopathy.Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation.Chemistry and biochemistry of lipid peroxidation products.Acrolein scavengers: reactivity, mechanism and impact on health.Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products.Role of lipid peroxidation-derived α, β-unsaturated aldehydes in vascular dysfunction.Endoplasmic reticulum stress in drug- and environmental toxicant-induced liver toxicity.SEURAT-1 liver gold reference compounds: a mechanism-based review.Eugenol and Its Role in Chronic Diseases.Acrylamide induces locomotor defects and degeneration of dopamine neurons in Caenorhabditis elegans.
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Molecular mechanisms of the conjugated alpha,beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 13 December 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Molecular mechanisms of the co ...... nd neurodegenerative diseases.
@en
Molecular mechanisms of the co ...... nd neurodegenerative diseases.
@nl
type
label
Molecular mechanisms of the co ...... nd neurodegenerative diseases.
@en
Molecular mechanisms of the co ...... nd neurodegenerative diseases.
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prefLabel
Molecular mechanisms of the co ...... nd neurodegenerative diseases.
@en
Molecular mechanisms of the co ...... nd neurodegenerative diseases.
@nl
P2093
P2860
P356
P1476
Molecular mechanisms of the co ...... nd neurodegenerative diseases.
@en
P2093
David S Barber
Richard M LoPachin
Terrence Gavin
P2860
P304
P356
10.1093/TOXSCI/KFM301
P577
2007-12-13T00:00:00Z