The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through β1 integrin.
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β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastomaBreast Cancer-Associated Fibroblasts: Where We Are and Where We Need to Goβ1 and β4 integrins: from breast development to clinical practiceBroad targeting of angiogenesis for cancer prevention and therapyIntegration of molecular profiling and chemical imaging to elucidate fibroblast-microenvironment impact on cancer cell phenotype and endocrine resistance in breast cancerEvolutionary foundations for cancer biologySimvastatin suppresses breast cancer cell proliferation induced by senescent cellsFunctional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity.Translational horizons in the tumor microenvironment: harnessing breakthroughs and targeting cures.Stromal cells in tumor microenvironment and breast cancerAcquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin aInsulin-like growth factor binding protein-3 inhibits cell adhesion via suppression of integrin β4 expression.Alternatively spliced tissue factor synergizes with the estrogen receptor pathway in promoting breast cancer progression.Loss of caveolin-1 alters extracellular matrix protein expression and ductal architecture in murine mammary glandsActivation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression.Ovarian cancer ascites increase Mcl-1 expression in tumor cells through ERK1/2-Elk-1 signaling to attenuate TRAIL-induced apoptosisInhibition of integrin β1 decreases the malignancy of ovarian cancer cells and potentiates anticancer therapy via the FAK/STAT1 signaling pathway.Stromal cells promote anti-estrogen resistance of breast cancer cells through an insulin-like growth factor binding protein 5 (IGFBP5)/B-cell leukemia/lymphoma 3 (Bcl-3) axisProlactin-induced protein as a potential therapy response marker of adjuvant chemotherapy in breast cancer patients.Metabolic coupling in urothelial bladder cancer compartments and its correlation to tumor aggressiveness.Expression of transmembrane protein 26 (TMEM26) in breast cancer and its association with drug response.Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.High expression of stromal PDGFRβ is associated with reduced benefit of tamoxifen in breast cancerEmerging targeted agents in metastatic breast cancer.Endocrine resistance in breast cancer.DNA methylome profiling beyond promoters - taking an epigenetic snapshot of the breast tumor microenvironment.miR-138-Mediated Regulation of KINDLIN-2 Expression Modulates Sensitivity to Chemotherapeutics.Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications.Laminin Modulates the Stem Cell Population in LM05-E Murine Breast Cancer Cells Through the Activation of the MAPK/ERK Pathway.Fibronectin: How Its Aberrant Expression in Tumors May Improve Therapeutic TargetingTumor-Initiating Cells: Emerging Biophysical Methods of Isolation.Extracellular Matrix/Integrin Signaling Promotes Resistance to Combined Inhibition of HER2 and PI3K in HER2+ Breast Cancer.Cancer-associated fibroblasts induce trastuzumab resistance in HER2 positive breast cancer cells.Tamoxifen selects for breast cancer cells with mammosphere forming capacity and increased growth rate.Mapping lung tumor cell drug responses as a function of matrix context and genotype using cell microarrays.Letrozole-induced functional changes in carcinoma-associated fibroblasts and their influence on breast cancer cell biology.Methods to Evaluate Cell Growth, Viability, and Response to Treatment in a Tissue Engineered Breast Cancer Model.Interleukin-6 receptor in spindle-shaped stromal cells, a prognostic determinant of early breast cancer.Targeting Fibronectin for Cancer Imaging and Therapy.
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The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through β1 integrin.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 21 September 2011
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The tumor microenvironment mod ...... bronectin through β1 integrin.
@en
The tumor microenvironment mod ...... bronectin through β1 integrin.
@nl
type
label
The tumor microenvironment mod ...... bronectin through β1 integrin.
@en
The tumor microenvironment mod ...... bronectin through β1 integrin.
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prefLabel
The tumor microenvironment mod ...... bronectin through β1 integrin.
@en
The tumor microenvironment mod ...... bronectin through β1 integrin.
@nl
P2093
P2860
P1476
The tumor microenvironment mod ...... bronectin through β1 integrin.
@en
P2093
Andrea Motter
Diego Raffo
Elisa Bal de Kier Joffé
Mina J Bissell
Osvaldo Pontiggia
Rocio Sampayo
P2860
P2888
P304
P356
10.1007/S10549-011-1766-X
P407
P577
2011-09-21T00:00:00Z