Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.

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MGMT testing--the challenges for biomarker-based glioma treatment.Effect of TET1 regulating MGMT on chemotherapy resistance of oral squamous cell carcinoma stem cells.Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication.

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Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.

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http://www.wikidata.org/entity/Q37038938

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 12 October 2012

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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Tumor-associated mutations in ...... duce DNA repair functionality.

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Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase

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Tumor-associated mutations in ...... duce DNA repair functionality.

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Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase

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Tumor-associated mutations in ...... duce DNA repair functionality.

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Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase

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Tumor-associated mutations in ...... duce DNA repair functionality.

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Alan C Sartorelli

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Joann B Sweasy

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Kimiko Ishiguro

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Patrick Sung

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Sara Rockwell

http://www.w3.org/2001/XMLSchema#string

Yanfeng Liu

http://www.w3.org/2001/XMLSchema#string

Youngho Kwon

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P2860

O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

MGMT gene silencing and benefit from temozolomide in glioblastoma.

Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase

Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine.

Repair of O(6)-alkylguanine by alkyltransferases.

Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation.

MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.

Alkylation damage in DNA and RNA--repair mechanisms and medical significance.

Human variants of O6-alkylguanine-DNA alkyltransferase.

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201-210

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scholarly article

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10.1002/MC.21964

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Nicolas Paquet

Kristy L Lamb

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2012-10-12T00:00:00Z

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232248099

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23065697

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3720794

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Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.

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P2860

P2860

Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.

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type

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P1433

P1476

P2093

P2860

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P356

P433

P478

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P577

P5875

P698

P932

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P1433

P1476

P2093

P2860

P304

P31

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P433

P478

P50

P577

P5875

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P932