Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4
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N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule PathwayRecent technical developments in the study of ER-associated degradationUbiquitin ligases in cholesterol metabolismQuality control of inner nuclear membrane proteins by the Asi complex.The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degronArms Race between Enveloped Viruses and the Host ERAD MachineryCleaning up in the endoplasmic reticulum: ubiquitin in chargeControlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope.Subcellular Fractionation Analysis of the Extraction of Ubiquitinated Polytopic Membrane Substrate during ER-Associated DegradationGlobal proteome turnover analyses of the Yeasts S. cerevisiae and S. pombe.STUbL-mediated degradation of the transcription factor MATĪ±2 requires degradation elements that coincide with corepressor binding sitesThe Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change.gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulumA MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.Direct and essential function for Hrd3 in ER-associated degradation.A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation.Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice.The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.Yeast lipid metabolism at a glance.Quality control: ER-associated degradation: protein quality control and beyondRegulation of Endoplasmic Reticulum-Associated Protein Degradation (ERAD) by Ubiquitin.Lipid droplet dynamics in budding yeast.Proteolytic regulation of metabolic enzymes by E3 ubiquitin ligase complexes: lessons from yeast.Increased lanosterol turnover: a metabolic burden for daunorubicin-resistant leukemia cells.Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases.The Membrane Associated RING-CH Proteins: A Family of E3 Ligases with Diverse Roles through the Cell.The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation.Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation.Interactions between intersubunit transmembrane domains regulate the chaperone-dependent degradation of an oligomeric membrane protein.Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway.Spatial control of lipid droplet proteins by the ERAD ubiquitin ligase Doa10.Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates.Proteostatic Tactics in the Strategy of Sterol Regulation.A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis.Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae.ERAD-dependent control of the Wnt secretory factor Evi.The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins.Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids.
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P2860
Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4
description
article cientĆfic
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article scientifique
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articolo scientifico
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artigo cientĆfico
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bilimsel makale
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scientific article published on 23 July 2013
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vedeckĆ½ ÄlĆ”nok
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vetenskaplig artikel
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videnskabelig artikel
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vÄdeckĆ½ ÄlĆ”nek
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name
Sterol homeostasis requires re ...... he ubiquitin ligase Doa10/Teb4
@en
Sterol homeostasis requires re ...... e ubiquitin ligase Doa10/Teb4.
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type
label
Sterol homeostasis requires re ...... he ubiquitin ligase Doa10/Teb4
@en
Sterol homeostasis requires re ...... e ubiquitin ligase Doa10/Teb4.
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prefLabel
Sterol homeostasis requires re ...... he ubiquitin ligase Doa10/Teb4
@en
Sterol homeostasis requires re ...... e ubiquitin ligase Doa10/Teb4.
@nl
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P1433
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Sterol homeostasis requires re ...... he ubiquitin ligase Doa10/Teb4
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P2093
Annamaria Ruggiano
Hans K Hannibal-Bach
P2860
P304
P356
10.7554/ELIFE.00953
P407
P577
2013-07-23T00:00:00Z