Potential adaptive function for altered long-term potentiation mechanisms in aging hippocampus
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Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717Hippocampal Gαq/₁₁ but not Gαo-coupled receptors are altered in aging.Alterations in synaptic plasticity coincide with deficits in spatial working memory in presymptomatic 3xTg-AD mice.Homeostatic disinhibition in the aging brain and Alzheimer's diseaseIntracellular redox state alters NMDA receptor response during aging through Ca2+/calmodulin-dependent protein kinase IISelective Vulnerabilities of N-methyl-D-aspartate (NMDA) Receptors During Brain Aging.Deep sleep and parietal cortex gene expression changes are related to cognitive deficits with age.Prominent hippocampal CA3 gene expression profile in neurocognitive aging.Non-coding RNA regulation of synaptic plasticity and memory: implications for aging.Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways.Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteomeCognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged ratsMolecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks.Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline.Long-Term Potentiation at CA3-CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress.The hippocampal neuroproteome with aging and cognitive decline: past progress and future directions.Behaviorally activated mRNA expression profiles produce signatures of learning and enhanced inhibition in aged rats with preserved memory.Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar rats.Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticityGABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged ratsHippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory.Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's diseaseNMDA Neurotransmission Dysfunction in Behavioral and Psychological Symptoms of Alzheimer's Disease.Characterization of CpG island DNA methylation of impairment-related genes in a rat model of cognitive agingAge-dependent alterations in cAMP signaling contribute to synaptic plasticity deficits following traumatic brain injuryLinking redox regulation of NMDAR synaptic function to cognitive decline during aging.The effects of aging on N-methyl-D-aspartate receptor subunits in the synaptic membrane and relationships to long-term spatial memory.Characterization of age-related changes in synaptic transmission onto F344 rat basal forebrain cholinergic neurons using a reduced synaptic preparationSenescent synapses and hippocampal circuit dynamics.Region-specific genetic alterations in the aging hippocampus: implications for cognitive agingIron deficiency on neuronal function.Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brainCalcium, Reactive Oxygen Species, and Synaptic Plasticity.Molecular and cellular aspects of age-related cognitive decline and Alzheimer's disease.Age-Induced Alterations in Hippocampal Function and Metabolism.CDK5 downregulation enhances synaptic plasticity.Inhibition of DNA Methylation Impairs Synaptic Plasticity during an Early Time Window in Rats.Age-dependent changes in autophosphorylation of alpha calcium/calmodulin dependent kinase II in hippocampus and amygdala after contextual fear conditioning.Proteolytic processing of the L-type Ca 2+ channel alpha 11.2 subunit in neurons.NMDA receptors in mouse anterior piriform cortex initialize early odor preference learning and L-type calcium channels engage for long-term memory.
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Potential adaptive function for altered long-term potentiation mechanisms in aging hippocampus
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on August 2008
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Potential adaptive function fo ...... echanisms in aging hippocampus
@en
Potential adaptive function fo ...... chanisms in aging hippocampus.
@nl
type
label
Potential adaptive function fo ...... echanisms in aging hippocampus
@en
Potential adaptive function fo ...... chanisms in aging hippocampus.
@nl
prefLabel
Potential adaptive function fo ...... echanisms in aging hippocampus
@en
Potential adaptive function fo ...... chanisms in aging hippocampus.
@nl
P2093
P2860
P1476
Potential adaptive function fo ...... echanisms in aging hippocampus
@en
P2093
Alfredo Kirkwood
Michela Gallagher
Pablo Muñoz
P2860
P304
P356
10.1523/JNEUROSCI.2036-08.2008
P407
P50
P577
2008-08-01T00:00:00Z