Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine.
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Unexpected consequences: exon skipping caused by CRISPR-generated mutationsA pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decayGuide Picker is a comprehensive design tool for visualizing and selecting guides for CRISPR experiments.Probing the canonicity of the Wnt/Wingless signaling pathway.UPF1 helicase promotes TSN-mediated miRNA decay.Highly efficient gene inactivation by adenoviral CRISPR/Cas9 in human primary cells.The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer.Novel NTRK1 mutations associated with congenital insensitivity to pain with anhidrosis verified by functional studies.Technical considerations for the use of CRISPR/Cas9 in hematology research.Truncating mutations of SPAST associated with hereditary spastic paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin.New variant and expression studies provide further insight into the genotype-phenotype correlation in YAP1-related developmental eye disorders.Bone marrow failure syndrome caused by homozygous frameshift mutation in the ERCC6L2 gene.BRCA1 loses the ring but lords over resistance.CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletionThe GBAP1 pseudogene acts as a ceRNA for the glucocerebrosidase gene GBA by sponging miR-22-3pHypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons.mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay.EPG5-Related Vici Syndrome: A Primary Defect of Autophagic Regulation with an Emerging Phenotype Overlapping with Mitochondrial Disorders.CXorf56, a dendritic neuronal protein, identified as a new candidate gene for X-linked intellectual disability.Functional analysis of thyroid hormone receptor beta in Xenopus tropicalis founders using CRISPR-Cas.Mutations in RARS cause a hypomyelination disorder akin to Pelizaeus-Merzbacher disease.CNGB3 mutation spectrum including copy number variations in 552 achromatopsia patients.Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay.Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer.OCT4/POU5F1 is required for NANOG expression in bovine blastocysts.Precise Excision of the CAG Tract from the Huntingtin Gene by Cas9 Nickases.A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97.Role of Complement in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy.Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System.An unclassified variant of CHD7 activates a cryptic splice site in a patient with CHARGE syndrome.CRISPR-induced exon skipping is dependent on premature termination codon mutations
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Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine.
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
@tr
scientific article published on June 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Leveraging Rules of Nonsense-M ...... ing and Personalized Medicine.
@en
Leveraging Rules of Nonsense-M ...... ing and Personalized Medicine.
@nl
type
label
Leveraging Rules of Nonsense-M ...... ing and Personalized Medicine.
@en
Leveraging Rules of Nonsense-M ...... ing and Personalized Medicine.
@nl
prefLabel
Leveraging Rules of Nonsense-M ...... ing and Personalized Medicine.
@en
Leveraging Rules of Nonsense-M ...... ing and Personalized Medicine.
@nl
P2860
P1433
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Leveraging Rules of Nonsense-M ...... ing and Personalized Medicine.
@en
P2093
Maximilian W Popp
P2860
P304
P356
10.1016/J.CELL.2016.05.053
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P577
2016-06-01T00:00:00Z