Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity.
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Use of Cell-Penetrating Peptides in Dendritic Cell-Based VaccinationIntracellular Delivery of Proteins with Cell-Penetrating Peptides for Therapeutic Uses in Human DiseaseCell-type specific penetrating peptides: therapeutic promises and challengesRecent Developments in Peptide-Based Nucleic Acid DeliveryAerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery SystemsA retro-inverso cell-penetrating peptide for siRNA delivery.Fusogenic-oligoarginine peptide-mediated delivery of siRNAs targeting the CIP2A oncogene into oral cancer cells.Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery.MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy.Nanodelivery in airway diseases: challenges and therapeutic applications.Impact of hydrogel nanoparticle size and functionalization on in vivo behavior for lung imaging and therapeuticsHigh-density lipoproteins for the systemic delivery of short interfering RNA.Immunological response to peptide nucleic acid and its peptide conjugate targeted to transactivation response (TAR) region of HIV-1 RNA genome.The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate.A novel in vivo siRNA delivery system specifically targeting liver cells for protection of ConA-induced fulminant hepatitisRNA interference for improving the outcome of islet transplantation.Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells.A bifurcated proteoglycan binding small molecule carrier for siRNA delivery.Optimized method for the synthesis and purification of adenosine--folic acid conjugates for use as transcription initiators in the preparation of modified RNA.Determination of key structure-activity relationships in siRNA delivery with a mixed micelle system.Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs.Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group.A role for peptides in overcoming endosomal entrapment in siRNA delivery - A focus on melittinBiodistribution and Efficacy of Targeted Pulmonary Delivery of a Protein Kinase C-δ Inhibitory Peptide: Impact on Indirect Lung Injury.dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitisControlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) expression by nanofiber-mediated siRNA gene silencing.Delivery of intracellular-acting biologics in pro-apoptotic therapies.Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells.Neutral polymeric micelles for RNA deliveryCellular uptake and cytotoxicity of drug-peptide conjugates regulated by conjugation siteFunctional Delivery of siRNA by Disulfide-Constrained Cyclic Amphipathic Peptides.Can RNAi-mediated hsp90α knockdown in combination with 17-AAG be a therapy for glioma?Enhancing the cellular uptake of siRNA duplexes following noncovalent packaging with protein transduction domain peptides.Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides.Self-assembled Tat nanofibers as effective drug carrier and transporter.New aspects of gene-silencing for the treatment of cardiovascular diseasesTargeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growthPeptide-mediated cellular delivery of oligonucleotide-based therapeutics in vitro: quantitative evaluation of overall efficacy employing easy to handle reporter systems.Targeted delivery systems for oligonucleotide therapeutics.Development of a Positive-readout Mouse Model of siRNA Pharmacodynamics.
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Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 21 August 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Lung delivery studies using siRNA conjugated to TAT
@nl
Lung delivery studies using si ...... induction of innate immunity.
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type
label
Lung delivery studies using siRNA conjugated to TAT
@nl
Lung delivery studies using si ...... induction of innate immunity.
@en
prefLabel
Lung delivery studies using siRNA conjugated to TAT
@nl
Lung delivery studies using si ...... induction of innate immunity.
@en
P2093
P2860
P50
P356
P1476
Lung delivery studies using si ...... d induction of innate immunity
@en
P2093
Andrew Evan Williams
Brian Stephen Sproat
John James Turner
Mark Andrew Lindsay
Michael John Gait
Peter John Barnes
P2860
P304
P356
10.1021/BC070077D
P577
2007-08-21T00:00:00Z