Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
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DockQ: A Quality Measure for Protein-Protein Docking Models.Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.Antigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike.Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope GlycoproteinPresenting native-like trimeric HIV-1 antigens with self-assembling nanoparticlesStructural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen.Native-like Env trimers as a platform for HIV-1 vaccine design.Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers.The HIV-1 envelope glycoprotein structure: nailing down a moving target.Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer.Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity.Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer.Conformational Heterogeneity of the HIV Envelope Glycan Shield.High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers.Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding.Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers.Computational study of HIV gp120 as a target for polyanionic entry inhibitors: Exploiting the V3 loop region.A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers.Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies.Progress in HIV vaccine developmentStabilizing HIV-1 envelope glycoprotein trimers to induce neutralizing antibodiesStrategies for a multi-stage neutralizing antibody-based HIV vaccineIdentification of a novel broadly HIV-1-neutralizing antibody from a CRF01_AE-infected Chinese donorEnhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic LiposomesRational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers
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P2860
Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 June 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Uncleaved prefusion-optimized ...... HIV-1 envelope metastability.
@en
Uncleaved prefusion-optimized ...... HIV-1 envelope metastability.
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type
label
Uncleaved prefusion-optimized ...... HIV-1 envelope metastability.
@en
Uncleaved prefusion-optimized ...... HIV-1 envelope metastability.
@nl
prefLabel
Uncleaved prefusion-optimized ...... HIV-1 envelope metastability.
@en
Uncleaved prefusion-optimized ...... HIV-1 envelope metastability.
@nl
P2093
P2860
P356
P1476
Uncleaved prefusion-optimized ...... f HIV-1 envelope metastability
@en
P2093
Andrew B Ward
Charles D Morris
Dennis R Burton
Ian A Wilson
Linling He
Natalia de Val
Parisa Azadnia
P2860
P2888
P356
10.1038/NCOMMS12040
P407
P577
2016-06-28T00:00:00Z