The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. - Wikidata - wikimedia - TriplyDB

The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.

The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.

http://www.wikidata.org/entity/Q37061110

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The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation Approaches of targeting Rho GTPases in cancer drug discovery Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms Function and regulation of the Rho guanine nucleotide exchange factor Trio Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Phage display discovery of novel molecular targets in glioblastoma-initiating cells Inference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of Cancer The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion.Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patients MiR-183 Regulates ITGB1P Expression and Promotes Invasion of Endometrial Stromal Cells.The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration.Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival.Therapeutic strategies for inhibiting invasion in glioblastoma.Epithelial cell transforming sequence 2 in human oral cancer.The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer.APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.Drosophila Abelson kinase mediates cell invasion and proliferation through two distinct MAPK pathways.Gene expression profiles of the NCI-60 human tumor cell lines define molecular interaction networks governing cell migration processes Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling.RasGRP3 regulates the migration of glioma cells via interaction with Arp3 VAV3 oncogene expression in colorectal cancer: clinical aspects and functional characterization.FilGAP, a Rac-specific Rho GTPase-activating protein, is a novel prognostic factor for follicular lymphoma.Rac signaling in breast cancer: a tale of GEFs and GAPs.The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5.Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells The chromosome 3q26 OncCassette: A multigenic driver of human cancer.The N-terminal 20-amino acid region of guanine nucleotide exchange factor Vav1 plays a distinguished role in T cell receptor-mediated calcium signaling.Novel interaction between the co-chaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen receptor activity and prostate cancer growth.Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasio Molecular Insights on Post-chemotherapy Retinoblastoma by Microarray Gene Expression Analysis The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation.The Guanine Nucleotide Exchange Factor SWAP-70 Modulates the Migration and Invasiveness of Human Malignant Glioma Cells.Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation.A role for activated Cdc42 in glioblastoma multiforme invasion.

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The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.

http://www.wikidata.org/entity/Q37061110

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2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

The guanine nucleotide exchang ...... sive behavior of glioblastoma.

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The guanine nucleotide exchang ...... sive behavior of glioblastoma.

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type

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The guanine nucleotide exchang ...... sive behavior of glioblastoma.

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The guanine nucleotide exchang ...... sive behavior of glioblastoma.

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prefLabel

The guanine nucleotide exchang ...... sive behavior of glioblastoma.

@en

The guanine nucleotide exchang ...... sive behavior of glioblastoma.

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AJPATH.2008.080043

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The American Journal of Pathology

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The guanine nucleotide exchang ...... asive behavior of glioblastoma

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Amparo Wolf

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Bodour Salhia

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Fiona Rutka

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James T Rutka

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Marc Symons

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Matthew Ennis

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Michael E Berens

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Mitsutoshi Nakada

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Nhan L Tran

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Wendy S McDonough

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P2860

A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs

Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

An ECT2-centralspindlin complex regulates the localization and function of RhoA

Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma

Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis

Regulatory and signaling properties of the Vav family

ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion.

Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis

Rho GTPases: biochemistry and biology

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