The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.
about
The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damageEct2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformationApproaches of targeting Rho GTPases in cancer drug discoveryRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseasePI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasmsFunction and regulation of the Rho guanine nucleotide exchange factor TrioRas superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Phage display discovery of novel molecular targets in glioblastoma-initiating cellsInference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of CancerThe N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion.Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patientsMiR-183 Regulates ITGB1P Expression and Promotes Invasion of Endometrial Stromal Cells.The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration.Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival.Therapeutic strategies for inhibiting invasion in glioblastoma.Epithelial cell transforming sequence 2 in human oral cancer.The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer.APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.Drosophila Abelson kinase mediates cell invasion and proliferation through two distinct MAPK pathways.Gene expression profiles of the NCI-60 human tumor cell lines define molecular interaction networks governing cell migration processesProapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cellsOncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylationTROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling.RasGRP3 regulates the migration of glioma cells via interaction with Arp3VAV3 oncogene expression in colorectal cancer: clinical aspects and functional characterization.FilGAP, a Rac-specific Rho GTPase-activating protein, is a novel prognostic factor for follicular lymphoma.Rac signaling in breast cancer: a tale of GEFs and GAPs.The APC/C Ubiquitin Ligase: From Cell Biology to TumorigenesisThe ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5.Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cellsThe chromosome 3q26 OncCassette: A multigenic driver of human cancer.The N-terminal 20-amino acid region of guanine nucleotide exchange factor Vav1 plays a distinguished role in T cell receptor-mediated calcium signaling.Novel interaction between the co-chaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen receptor activity and prostate cancer growth.Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasioMolecular Insights on Post-chemotherapy Retinoblastoma by Microarray Gene Expression AnalysisThe Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation.The Guanine Nucleotide Exchange Factor SWAP-70 Modulates the Migration and Invasiveness of Human Malignant Glioma Cells.Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation.A role for activated Cdc42 in glioblastoma multiforme invasion.
P2860
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P2860
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
The guanine nucleotide exchang ...... sive behavior of glioblastoma.
@en
The guanine nucleotide exchang ...... sive behavior of glioblastoma.
@nl
type
label
The guanine nucleotide exchang ...... sive behavior of glioblastoma.
@en
The guanine nucleotide exchang ...... sive behavior of glioblastoma.
@nl
prefLabel
The guanine nucleotide exchang ...... sive behavior of glioblastoma.
@en
The guanine nucleotide exchang ...... sive behavior of glioblastoma.
@nl
P2093
P2860
P1476
The guanine nucleotide exchang ...... asive behavior of glioblastoma
@en
P2093
Amparo Wolf
Bodour Salhia
Fiona Rutka
James T Rutka
Marc Symons
Matthew Ennis
Michael E Berens
Mitsutoshi Nakada
Nhan L Tran
Wendy S McDonough
P2860
P304
P356
10.2353/AJPATH.2008.080043
P407
P577
2008-11-13T00:00:00Z