Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children
about
Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System InfectionsThe influence of host genetics on erythrocytes and malaria infection: is there therapeutic potential?Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical ApproachThe role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis researchCurrent Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular CoagulationVascular dysfunction as a target for adjuvant therapy in cerebral malariaMycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer LesionsInflammasome in platelets: allying coagulation and inflammation in infectious and sterile diseases?The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccinePiecing together the puzzle of severe malaria.Magnetic Resonance Imaging of Cerebral Malaria Patients Reveals Distinct Pathogenetic Processes in Different Parts of the Brain.The role of EPCR in the pathogenesis of severe malariaEndothelial glycocalyx on brain endothelial cells is lost in experimental cerebral malariaEvidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.The systemic pathology of cerebral malaria in African childrenEndothelial cell protein C receptor: a multiliganded and multifunctional receptorStructural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria.Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains.EPCR and Malaria Severity: The Center of a Perfect Storm.Differential PfEMP1 expression is associated with cerebral malaria pathology.Production, fate and pathogenicity of plasma microparticles in murine cerebral malaria.Plasmodium falciparum antigenic variation: relationships between widespread endothelial activation, parasite PfEMP1 expression and severe malaria.Endothelial protein C receptor gene variants not associated with severe malaria in ghanaian children.Activated protein C: biased for translation.Severity of retinopathy parallels the degree of parasite sequestration in the eyes and brains of malawian children with fatal cerebral malariaBrain swelling and death in children with cerebral malariaα2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes.Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding.Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV CoinfectionPathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches.CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature.Diverse functional outcomes of Plasmodium falciparum ligation of EPCR: potential implications for malarial pathogenesis.Plasmodium falciparum adhesion domains linked to severe malaria differ in blockade of endothelial protein C receptor.Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania.Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding.Differential Plasmodium falciparum surface antigen expression among children with Malarial Retinopathy.Alterations of blood coagulation in controlled human malaria infection.Activated Neutrophils Are Associated with Pediatric Cerebral Malaria Vasculopathy in Malawian ChildrenThe endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria.Plasma levels of eight different mediators and their potential as biomarkers of various clinical malaria conditions in African children.
P2860
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P2860
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children
description
2013 nî lūn-bûn
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2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
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2013年学术文章
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2013年學術文章
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name
Loss of endothelial protein C ...... al malaria in African children
@en
Loss of endothelial protein C ...... l malaria in African children.
@nl
type
label
Loss of endothelial protein C ...... al malaria in African children
@en
Loss of endothelial protein C ...... l malaria in African children.
@nl
prefLabel
Loss of endothelial protein C ...... al malaria in African children
@en
Loss of endothelial protein C ...... l malaria in African children.
@nl
P2093
P2860
P50
P921
P1433
P1476
Loss of endothelial protein C ...... al malaria in African children
@en
P2093
Brian Faragher
Charles T Esmon
Cheng-Hock Toh
Christopher A Moxon
Colin Downey
Karl B Seydel
Ngawina V Chisala
Samuel C Wassmer
P2860
P304
P356
10.1182/BLOOD-2013-03-490219
P407
P577
2013-06-05T00:00:00Z