Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
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Inhibition of HIV-1 replication by a bis-thiadiazolbenzene-1,2-diamine that chelates zinc ions from retroviral nucleocapsid zinc fingersA single zinc finger optimizes the DNA interactions of the nucleocapsid protein of the yeast retrotransposon Ty3.Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide.Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer.Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity.Biophysical characterization of DNA binding from single molecule force measurementsIdentification of HIV-1 inhibitors targeting the nucleocapsid protein.Single aromatic residue location alters nucleic acid binding and chaperone function of FIV nucleocapsid protein.Advances in targeting nucleocapsid-nucleic acid interactions in HIV-1 therapy.Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription.Identification of a methylated oligoribonucleotide as a potent inhibitor of HIV-1 reverse transcription complex.The dynamics of zinc sites in proteins: electronic basis for coordination sphere expansion at structural sites.HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors.Ty1 retrovirus-like element Gag contains overlapping restriction factor and nucleic acid chaperone functions.Identification and characterization of a new type of inhibitor against the human immunodeficiency virus type-1 nucleocapsid protein.Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7.An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV TransmissionSite-selective probing of cTAR destabilization highlights the necessary plasticity of the HIV-1 nucleocapsid protein to chaperone the first strand transfer.Nucleocapsid protein function in early infection processes.When is it time for reverse transcription to start and go?The N-terminal zinc finger and flanking basic domains represent the minimal region of the human immunodeficiency virus type-1 nucleocapsid protein for targeting chaperone function.Potential inhibition of HIV-1 encapsidation by oligoribonucleotide-dendrimer nanoparticle complexes.Differential contribution of basic residues to HIV-1 nucleocapsid protein's nucleic acid chaperone function and retroviral replication.Properties and functions of the nucleocapsid protein in virus assembly.Zinc finger proteins as templates for metal ion exchange and ligand reactivity. Chemical and biological consequences.Cell biology of retroviral RNA packaging.Characterization of the inhibition mechanism of HIV-1 nucleocapsid protein chaperone activities by methylated oligoribonucleotides.The conserved N-terminal basic residues and zinc-finger motifs of HIV-1 nucleocapsid restrict the viral cDNA synthesis during virus formation and maturation.Current Peptide and Protein Candidates Challenging HIV Therapy beyond the Vaccine Era.6th international symposium on retroviral nucleocapsid.Alpha-helicoidal HEAT-like Repeat Proteins (αRep) Selected as Interactors of HIV-1 Nucleocapsid Negatively Interfere with Viral Genome Packaging and Virus Maturation.Selectivity of arsenite interaction with zinc finger proteins.Design, synthesis and biological evaluation of TAR and cTAR binders as HIV-1 nucleocapsid inhibitors
P2860
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P2860
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on January 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
@en
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
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type
label
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
@en
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
@nl
prefLabel
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
@en
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.
@nl
P2093
P1476
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy
@en
P2093
Chang Zhi Dong
Hugues de Rocquigny
Jean-Luc Darlix
Sergiy Avilov
P356
10.2174/138955708783331603
P577
2008-01-01T00:00:00Z