Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases.
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Complexity of vitamin E metabolismIn vitro stable isotope labeling for discovery of novel metabolites by liquid chromatography-mass spectrometry: Confirmation of gamma-tocopherol metabolism in human A549 cell.Natural forms of vitamin E and 13'-carboxychromanol, a long-chain vitamin E metabolite, inhibit leukotriene generation from stimulated neutrophils by blocking calcium influx and suppressing 5-lipoxygenase activity, respectively.Analysis of multiple metabolites of tocopherols and tocotrienols in mice and humans.Cancer-preventive activities of tocopherols and tocotrienols.Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapyTocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases.Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols.Pharmacological potential of tocotrienols: a review.Clinical Significance of Female-hormones and Cytokines in Breast Cancer Patients Complicated with Aromatase Inhibitor-related Osteoarthropathy - Efficacy of Vitamin E.The anti-inflammatory role of vitamin e in prevention of osteoporosis.Metabolism of tocotrienols in animals and synergistic inhibitory actions of tocotrienols with atorvastatin in cancer cellsWhy tocotrienols work better: insights into the in vitro anti-cancer mechanism of vitamin E.Chemopreventive activity of vitamin E in breast cancer: a focus on γ- and δ-tocopherolGamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide.Omics approaches in cystic fibrosis research: a focus on oxylipin profiling in airway secretions.Analysis of vitamin E metabolites including carboxychromanols and sulfated derivatives using LC/MS/MS.Vitamin E for the treatment of children with hepatitis B e antigen-positive chronic hepatitis: A systematic review and meta-analysisDoes vitamin E prevent or promote cancer?γ-Tocotrienol inhibits lipopolysaccharide-induced interlukin-6 and granulocyte colony-stimulating factor by suppressing C/EBPβ and NF-κB in macrophagesVitamin E, γ-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers.Vitamin E metabolite 13'-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in miceTocopherols in cancer: An updateα-Tocopheryl Succinate Inhibits Osteoclast Formation by Suppressing Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL) Expression and Bone Resorption.Optimization of the enzymatic hydrolysis and analysis of plasma conjugated gamma-CEHC and sulfated long-chain carboxychromanols, metabolites of vitamin EGamma-tocopherol attenuates moderate but not severe colitis and suppresses moderate colitis-promoted colon tumorigenesis in mice.Metabolomic screening of pre-diagnostic serum samples identifies association between α- and γ-tocopherols and glioblastoma risk.Inhibitory effects of different forms of tocopherols, tocopherol phosphates, and tocopherol quinones on growth of colon cancer cells.Regulatory metabolites of vitamin E and their putative relevance for atherogenesis.Supplementation with γ-tocopherol attenuates endotoxin-induced airway neutrophil and mucous cell responses in rats.Recent Pathophysiological Aspects of Peyronie's Disease: Role of Free Radicals, Rationale, and Therapeutic Implications for Antioxidant Treatment-Literature Review.Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells.Gamma-tocopherol enhances apoptotic effects of lovastatin in human colorectal carcinoma cell line (HT29).Enzymatic sulfation of tocopherols and tocopherol metabolites by human cytosolic sulfotransferases.Gamma-tocotrienol and gamma-tocopherol are primarily metabolized to conjugated 2-(beta-carboxyethyl)-6-hydroxy-2,7,8-trimethylchroman and sulfated long-chain carboxychromanols in rats.α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages.Effectiveness of antioxidants (propolis, blueberry, vitamin E) associated with verapamil in the medical management of Peyronie's disease: a study of 151 cases.Protective effect of alpha-tocopherol isomer from vitamin E against the H2O2 induced toxicity on dental pulp cells.Two faces of vitamin e in the lung.Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation.
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P2860
Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Long-chain carboxychromanols, ...... inhibitors of cyclooxygenases.
@en
Long-chain carboxychromanols, ...... inhibitors of cyclooxygenases.
@nl
type
label
Long-chain carboxychromanols, ...... inhibitors of cyclooxygenases.
@en
Long-chain carboxychromanols, ...... inhibitors of cyclooxygenases.
@nl
prefLabel
Long-chain carboxychromanols, ...... inhibitors of cyclooxygenases.
@en
Long-chain carboxychromanols, ...... inhibitors of cyclooxygenases.
@nl
P2093
P2860
P356
P1476
Long-chain carboxychromanols, ...... inhibitors of cyclooxygenases.
@en
P2093
Jianjie Huang
Markus A Lill
Matthew L Danielson
Qing Jiang
Xinmin Yin
P2860
P304
20464-20469
P356
10.1073/PNAS.0810962106
P407
P577
2008-12-11T00:00:00Z